Inflammasome-Independent Roles of NLR and ALR Family Members.
Inflammasome-Independent Roles of NLR and ALR Family Members.
复制标题
NLR 和 ALR 家族成员的独立于炎症体的作用。
DOI：
10.1007/978-1-0716-3350-2_2
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Sutterwala,FayyazS
中科院分区：
文献类型：
--
作者：
Gupta,Suman;Cassel,SuzanneL;Sutterwala,FayyazS
模式识别受体，包括NLR和ALR家族的成员，对于识别病原体和宿主衍生的危险信号都是必不可少的。这些家族中的几个成员，包括NLRP1、NLRP3、NLRC4和AIM2，能够形成多蛋白复合体，称为炎症体，导致促炎caspase-1的激活。然而，除了炎性小体的形成外，这些家族中的一些成员还发挥着非炎性小体的功能。在这里，我们将讨论NLRC4、NLRP12和AIM2的炎症体非依赖性功能，并研究它们在调节先天性和获得性免疫过程中的作用。
Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of forming multiprotein complexes, called inflammasomes, that result in the activation of pro-inflammatory caspase-1. However, in addition to the formation of inflammasomes, a number of these family members exert inflammasome-independent functions. Here, we will discuss inflammasome-independent functions of NLRC4, NLRP12, and AIM2 and examine their roles in regulating innate and adaptive immune processes.