Non-calcified coronary plaque volume inversely related to CD4(+) T-cell count in HIV infection.
Non-calcified coronary plaque volume inversely related to CD4(+) T-cell count in HIV infection.
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DOI：
10.3851/imp1994
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发表时间：
2012
影响因子：
1.2
通讯作者：
Gharib AM
中科院分区：
文献类型：
--
作者：
Duarte H;Matta JR;Muldoon N;Masur H;Hadigan C;Gharib AM
Non-calcified coronary artery plaque (NCAP) may be an important predictor of cardiovascular events, however, few studies have directly measured NCAP in HIV-infected individuals. We completed a prospective cross-sectional evaluation of NCAP and coronary calcium scores using CT angiography in HIV-infected subjects (n=26) without known coronary artery disease (CAD), but who had one or more CAD risk factor and compared them to controls matched on age, race, sex, body mass index and Framingham risk score (n=26). There was no difference in coronary calcium scores (114 ± 218 vs. 124 ± 298 p=0.89) or NCAP volume (65 ± 86 mm3 vs. 63 ± 82 mm3, p=0.38) between HIV-infected subjects and controls, respectively. Among HIV-infected subjects, lower CD4 count was associated with increased NCAP volume (r=-0.52, p=0.006). CD4 count remained a significant predictor of NCAP in a multivariate analysis that adjusted for age and duration of antiretroviral therapy. Plaque burden is similar between HIV-infected and uninfected individuals when matched on traditional CAD risk factors, however immune function may mediate the development of atherosclerosis in HIV infection.
