Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.
Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.
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DOI：
10.1002/jcph.1028
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发表时间：
2018-01
影响因子：
2.9
通讯作者：
Pollack BP
中科院分区：
文献类型：
--
作者：
Kersh AE;Ng S;Chang YM;Sasaki M;Thomas SN;Kissick HT;Lesinski GB;Kudchadkar RR;Waller EK;Pollack BP
目前处于治疗晚期癌症最前沿的两种药理学方法是那些以破坏肿瘤细胞内关键的生长/生存信号通路为中心的方法（通常称为“靶向治疗”）和那些以增强患者免疫系统产生抗肿瘤反应的能力为中心的方法（免疫疗法）。最大限度地提高对这两种方法的反应需要了解特定患者肿瘤中存在的致癌事件以及肿瘤免疫微环境的性质。尽管这两种方式是独立开发和最初使用的，但组合方案现在正在临床试验中进行测试，这强调了了解靶向治疗如何影响免疫事件的必要性。转化研究和临床前模型已经证明，靶向治疗可以影响免疫细胞运输、趋化因子和细胞因子的产生和反应、抗原呈递以及与抗肿瘤免疫和免疫稳态相关的其他过程。此外，由于靶向治疗的这些和其他作用发生在非恶性细胞中，因此正在评估靶向治疗在肿瘤学之外的应用。
Two pharmacologic approaches that are currently at the forefront of treating advanced cancer are those that center on disrupting critical growth/survival signaling pathways within tumor cells (commonly referred to as “targeted therapies”) and those that center on enhancing the capacity of a patient’s immune system to mount an antitumor response (immunotherapy). Maximizing responses to both of these approaches requires an understanding of the oncogenic events present in a given patient’s tumor and the nature of the tumor-immune microenvironment. Although these 2 modalities were developed and initially used independently, combination regimens are now being tested in clinical trials, underscoring the need to understand how targeted therapies influence immunologic events. Translational studies and preclinical models have demonstrated that targeted therapies can influence immune cell trafficking, the production of and response to chemokines and cytokines, antigen presentation, and other processes relevant to antitumor immunity and immune homeostasis. Moreover, because these and other effects of targeted therapies occur in nonmalignant cells, targeted therapies are being evaluated for use in applications outside of oncology.
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影响因子：
7
作者：
Curtsinger JM;Mescher MF
通讯作者：
Mescher MF
影响因子：
10.3
作者：
Bissonnette, R.;Papp, K. A.;Ports, W. C.
通讯作者：
Ports, W. C.
影响因子：
11.4
作者：
Cwynarski, K;Laylor, R;Dazzi, F
通讯作者：
Dazzi, F
影响因子：
7.7
作者：
Chattopadhyay, Saurabh;Veleeparambil, Manoj;Sen, Ganes C.
通讯作者：
Sen, Ganes C.
影响因子：
10.5
作者：
Ancrile, Brooke;Lim, Kian-Huat;Counter, Christopher M.
通讯作者：
Counter, Christopher M.