Hypertension accelerates age-related intrarenal small artery (IRSA) remodelling and stiffness in rats with possible involvement of AGEs and RAGE
Hypertension accelerates age-related intrarenal small artery (IRSA) remodelling and stiffness in rats with possible involvement of AGEs and RAGE
复制标题
高血压加速大鼠与年龄相关的肾内小动脉 (IRSA) 重塑和僵化，可能与 AGE 和 RAGE 相关
DOI：
10.14670/hh-18-141
复制
发表时间：
2020-01-01
影响因子：
2
通讯作者：
Hong, Huashan
中科院分区：
文献类型：
--
作者：
Bai, Yajing;Shi, Xiaoyun;Hong, Huashan
**目的**：研究自发性高血压大鼠（SHRs）肾内小动脉（IRSAs）随年龄增长在形态学、晚期糖基化终末产物（AGEs）及其受体RAGE方面的变化，并探究高血压、AGEs和RAGE在大鼠IRSAs随年龄增长而发生重塑和僵硬进展过程中可能发挥的作用。
**方法**：对老龄SHRs和老龄血压正常的Wistar Kyoto（WKY）大鼠进行研究。测量最小肾血管阻力（minRVR）。同时检测肾弓状动脉（RAAs）和小叶间动脉（RILAs）中α - 平滑肌肌动蛋白、增殖细胞核抗原、AGEs、RAGE的表达情况，以及血浆中AGEs的浓度。
**结果**：SHRs的IRSA最小肾血管阻力、RILAs和RAAs的管壁增厚、细胞增殖及胶原沉积随年龄增长逐渐增加，且24周龄SHRs的上述指标显著高于同龄WKY大鼠（p （此处p后似乎缺少具体比较内容） ）
Objectives. To study changes in morphology, advanced glycation end products (AGEs) and the AGEs receptor, RAGE, that occur with ageing in intrarenal small arteries (IRSAs) of spontaneously hypertensive rats (SHRs) and to investigate the possible roles of hypertension, AGEs and RAGE in the progression of IRSA remodelling and stiffness with ageing in rats. METHODS: Ageing SHRs and ageing normotensive Wistar Kyoto (WKY) rats were studied. The minimal renal vascular resistance (minRVR) was measured. Renal arcuate arteries (RAAs) and interlobular arteries (RILAs), the expression of alpha-smooth muscle actin, proliferating cell nuclear antigen, AGEs, RAGE and the plasma concentrations of AGEs were also examined. RESULTS: The IRSA minRVR, wall thickening, cell proliferation and collagen deposition in RILAs and RAAs gradually increased with age in SHRs and were much higher in 24-week-old SHRs than in age-matched WKY rats (p