Inflammation and metabolic disorders
Inflammation and metabolic disorders
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DOI：
10.1038/nature05485
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发表时间：
2006-12-14
期刊：
影响因子：
64.8
通讯作者：
Hotamisligil, Goekhan S.
中科院分区：
文献类型：
--
作者：
Hotamisligil, Goekhan S.
代谢和免疫系统是生存的最基本要求之一。许多代谢和免疫反应途径或营养和病原体传感系统在整个物种中进化保守。因此，免疫反应和代谢调节是高度整合的，每一个的适当功能都依赖于另一个。这个界面可以被视为一个中央稳态机制，其功能障碍可以导致一系列慢性代谢紊乱，特别是肥胖症，2型糖尿病和心血管疾病。这些疾病合在一起构成了当前对全球人类健康和福祉的最大威胁。
Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.