Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer.
Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer.
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DOI：
10.1038/bjc.2012.540
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发表时间：
2013-01-15
影响因子：
8.8
通讯作者：
Sturge, J.
中科院分区：
文献类型：
--
作者：
Palmieri, C.;Caley, M. P.;Purshouse, K.;Fonseca, A-V;Rodriguez-Teja, M.;Kogianni, G.;Woodley, L.;Odendaal, J.;Elliott, K.;Waxman, J.;Sturge, J.
Endo180 （CD280; MRC2; uPARAP）依赖性胶原重构在原发性肿瘤和骨转移中失调。本研究证实可溶性Endo180在乳腺癌转移诊断中的释放和诊断准确性。在BCa细胞条件培养基和BCa患者血浆中，根据疾病状态和双膦酸盐治疗进行分层，对Endo180进行定量（n=88）。所有p值均来自双侧检验。Endo180是通过MCF-7和MDA-MB-231 BCa细胞株表面的外畴脱落释放的。血浆Endo180在复发/转移性BCa中（1.71±0.87,n=59）明显高于早期/局部BCa(0.92±0.37,n=29) （P<0.0001）。转移分类的真阳性率和假阳性率分别为：参比标准ca15 -3抗原（28 U ml−1）为85%/50%；Endo180的≥97%/大于或等于36%；ca15 -3抗原+Endo180的≥97%/小于32%。双膦酸盐治疗与骨转移的BCa患者Endo180水平降低相关（P=0.011; n=42）。双磷酸盐初始患者（n=57）的真/假阳性率为：CA 15-3抗原68%/45%；Endo180≥95%/大于或等于20%；ca15 -3抗原+Endo180的≥92%/大于或等于21%。Endo180是转移性BCa中由双膦酸盐调节的潜在标志物。
Endo180 (CD280; MRC2; uPARAP)-dependent collagen remodelling is dysregulated in primary tumours and bone metastasis. Here, we confirm the release and diagnostic accuracy of soluble Endo180 for diagnosing metastasis in breast cancer (BCa). Endo180 was quantified in BCa cell conditioned medium and plasma from BCa patients stratified according to disease status and bisphosphonate treatment (n=88). All P-values are from two-sided tests. Endo180 is released by ectodomain shedding from the surface of MCF-7 and MDA-MB-231 BCa cell lines. Plasma Endo180 was significantly higher in recurrent/metastatic (1.71±0.87; n=59) vs early/localised (0.92±0.37; n=29) BCa (P<0.0001). True/false-positive rates for metastasis classification were: 85%/50% for the reference standard, CA 15-3 antigen (28 U ml−1); ⩽97%/⩾36% for Endo180; and ⩽97%/⩾32% for CA 15-3 antigen+Endo180. Bisphosphonate treatment was associated with reduced Endo180 levels in BCa patients with bone metastasis (P=0.011; n=42). True/false-positive rates in bisphosphonate-naive patients (n=57) were: 68%/45% for CA 15-3 antigen; ⩽95%/⩾20% for Endo180; and ⩽92%/⩾21% for CA 15-3 antigen+Endo180. Endo180 is a potential marker modulated by bisphosphonates in metastatic BCa.
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影响因子：
51.1
作者：
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通讯作者：
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影响因子：
7.3
作者：
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通讯作者：
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影响因子：
4.1
作者：
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影响因子：
158.5
作者：
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关键评估用于分类或预测的生物标志物的准确性：研究设计标准。
影响因子：
10.3
作者：
Pepe, Margaret S.;Feng, Ziding;Janes, Holly;Bossuyt, Patrick M.;Potter, John D.
通讯作者：
Potter, John D.