Evidence for two CMP-N-acetylneuraminic acid: lactose sialyltransferases in rat, porcine, bovine, and human liver.
Evidence for two CMP-N-acetylneuraminic acid: lactose sialyltransferases in rat, porcine, bovine, and human liver.
复制标题
两种 CMP-N-乙酰神经氨酸的证据：大鼠、猪、牛和人肝脏中的乳糖唾液酸转移酶。
DOI：
10.1139/o72-141
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
H. Schachter
中科院分区：
文献类型：
--
作者：
R. L. Hudgin;H. Schachter
有证据表明，两种唾液酸转移酶可催化大鼠、猪、牛肉和人类胎儿和成人肝脏中唾液酸-(2 → 3)-乳糖和唾液酸-(2 → 6)-乳糖的形成。在大鼠和猪肝脏中，这些产物的形成速率之比随年龄而变化。对于所有四个物种，该比率也随着孵化 pH 值的变化而变化。讨论了这些发现对糖蛋白生物合成控制的影响。
Evidence is presented for two sialyltransferases catalyzing formation of sialyl-(2 → 3)-lactose and sialyl-(2 → 6)-lactose in fetal and adult livers from rats, pigs, beef, and humans. In rat and porcine liver, the ratio of the rates of formation of these products varied with age. This ratio also varied with the pH of incubation for all four species. The implications of these findings in the control of glycoprotein biosynthesis are discussed.