Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations.
Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations.
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DOI：
10.1097/01.wnn.0000119564.08162.46
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发表时间：
2004-06-01
期刊：
影响因子：
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通讯作者：
Libon, David J
中科院分区：
文献类型：
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作者：
Cosentino, Stephanie;Jefferson, Angela;Libon, David J
目的：提出了一个时钟绘图测试评分系统，以探索最初诊断为阿尔茨海默病、与白质改变相关的缺血性血管性痴呆和帕金森病的患者时钟绘图背后的神经心理学/神经解剖学成分。方法：对 14 个时钟绘图测试错误进行评分，创建 4 个时钟绘图测试子量表，评估不同的潜在认知操作。结果：在命令条件下，时间子量表的错误与执行控制措施的损害相关。在复制条件下，坚持/刺激拉动量表的错误也与执行控制措施相关。比较了磁共振成像白质轻度（低）改变、白质显着（高）改变和帕金森病的患者。在命令条件下，低白质改变组的总错误少于帕金森病组。在复制条件下，低白质改变组在时间、空间布局和刺激时钟绘图测试分量表上的错误比高白质改变组或帕金森病组少。白质高改变组和帕金森病组之间几乎没有发现差异。讨论：我们的数据表明，与大规模皮质-皮质下神经网络中断相关的对执行控制的大量需求是轻度痴呆患者时钟绘制受损的基础。
OBJECTIVES: A clock drawing test scoring system is presented to explore the neuropsychological/neuroanatomic components underlying clock drawing in patients initially diagnosed with Alzheimer disease, ischemic vascular dementia associated with white matter alterations, and Parkinson disease.METHODS: Fourteen clock drawing test errors were scored to create 4 clock drawing test subscales that assess different underlying cognitive operations.RESULTS: In the command condition, errors on the Time subscale were correlated with impairment on executive control measures. In the copy condition, errors on the Perseveration/Pull to Stimulus subscale was also correlated with executive control measures. Patients presenting with mild (low) magnetic resonance imaging white matter alterations, significant (high) white matter alterations, and Parkinson disease were compared. In the command condition, the low white matter alterations group made fewer total errors than the Parkinson disease group. In the copy condition, the low white matter alterations group made fewer errors on the Time, Spatial Layout, and Perseveration/Pull to Stimulus clock drawing test subscales than the high white matter alterations or Parkinson disease groups. Few differences were noted between the high white matter alterations and Parkinson disease groups.DISCUSSION: Our data suggest that heavy demands on executive control associated with the interruption of large-scale cortical-subcortical neural networks underlie impairment in clock drawing in mild dementia.