Cell cannibalism: Diagnostic marker of malignancy
Cell cannibalism: Diagnostic marker of malignancy
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DOI：
10.1002/dc.10234
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发表时间：
2003-02-01
影响因子：
1.3
通讯作者：
Dey, P
中科院分区：
文献类型：
--
作者：
Gupta, K;Dey, P
在本研究中，我们试图找出细胞学相关性的食人作为一个可靠的特征恶性积液和尿液细胞学。我们随机选择了总共40个病例，包括恶性积液、良性积液、恶性尿液样本和良性尿液样本各10个。评估这些涂片是否存在细胞自相残杀。计数每100个肿瘤细胞中的同类相食细胞数。恶性融合病例中的同类相食细胞（3.4/100细胞）多于恶性尿液病例中的同类相食细胞（2/100细胞）。在良性条件下没有一个同类相食的细胞。恶性肿瘤与良性肿瘤相比，同类相食细胞数量的增加具有高度显著性（P > 0.0000，Student's t检验）。本研究强调了食人现象在恶性尿液和渗出液细胞学中的意义。我们认为细胞自食是恶性肿瘤的一个可靠的细胞学特征。(C)2003 Wiley-Liss，Inc.
In this study, we tried to find out the cytological relevance of cannibalism as a dependable feature of malignancy in effusion and urine cytology. We randomly selected a total of 40 cases consisting of 10 each of malignant effusion, benign effusion, malignant urine samples, and benign urine samples. These smears were assessed for the presence of cell cannibalism. The number of cannibalistic cells/100 tumor cells was counted. The cannibalistic cells were seen more commonly in malignant of fusion cases (3.4/100 cells) compared with malignant urine Cases (2/100 cells). There was not a single cannibalistic cell in benign conditions. The finding of an increased number of cannibalistic cell was highly significant in malignant versus benign samples (P > 0.0000, Student's t-test). The present study highlights the significance of cannibalism in malignant urine and effusion cytology. We suggest that cell cannibalism is a dependable cytological feature of malignancy. (C) 2003 Wiley-Liss, Inc.