GENOTOXICITY OF FUNGAL METABOLITES RELATED TO AFLATOXIN-B1 BIOSYNTHESIS
GENOTOXICITY OF FUNGAL METABOLITES RELATED TO AFLATOXIN-B1 BIOSYNTHESIS
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DOI：
10.1016/s0165-7992(85)80021-x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
HAMASAKI, T
中科院分区：
文献类型：
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作者：
MORI, H;KITAMURA, J;HAMASAKI, T
通过肝细胞原代培养（HPC）/DNA修复试验和沙门氏菌微粒体诱变试验[使用人成纤维细胞]，检查了与黄曲霉毒素B1 [人类食品和动物饲料的污染物]代谢相关的几种蒽醌化合物的遗传毒性，并与黄曲霉毒素生物合成途径的强效诱变和遗传毒性中间体versicolorins A和B进行了比较。发现6，8-O-二甲基-versicolorin A、B和6-脱氧versicolorin A具有强烈的致突变性和遗传毒性。在HPC/DNA修复试验中，versicolorin A和6，8-O-dimethylversicolorin A的遗传毒性分别强于versicolorin B和6，8-O-dimethylversicolorin B。不具有双呋喃环的Nidurufin和去甲甲异喹啉酸表现出可疑的致突变活性，但无遗传毒性。怀疑6，8-O-二甲基versicolorin A、B和6-脱氧versicolorin A以及versicolorin A和B是遗传毒性致癌物。
The genotoxicity of several anthraquinone compounds metabolically related to aflatoxin B1 [a contaminant of human food stuffs and animal feeds] was examined by means of the hepatocyte primary culture (HPC)/DNA repair test and the Salmonella microsome mutagenesis test [using human fibroblasts], and compared to versicolorins A and B which are potent mutagenic and genotoxic intermediates of the aflatoxin biosynthetic pathway. 6,8-O-Dimethyl-versicolorins A, B and 6-deoxyversicolorin A were found to be strongly mutagenic and genotoxic. Genotoxicity of versicolorin A and 6,8-O-dimethylversicolorin A was stronger than that of versicolorin B and 6,8-O-dimethylversicolorin B, respectively, in the HPC/DNA repair test. Nidurufin and norsolorinic acid, which do not possess a bisfuran ring, exhibited questionable activities for mutagenicity and no genotoxicity. It is suspected that 6,8-O-dimethylversicolorins A, B and 6-deoxyversicolorin A as well as versicolorins A and B are genotoxic carcinogens.