Synthesis of the C7-26 Fragment of Amphidinolides G and H
Synthesis of the C7-26 Fragment of Amphidinolides G and H
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DOI：
10.1021/ol201547q
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发表时间：
2011-08-05
期刊：
影响因子：
5.2
通讯作者：
Nishiyama, Shigeru
中科院分区：
文献类型：
--
作者：
Hara, Akihiro;Morimoto, Ryo;Nishiyama, Shigeru
本文报道了一种合成两性环内酯G和H的C7-26片段的新方法。在序列中，该片段的C7-18部分使用乙炔基偶联方案合成，而Evans烷基化和Sharpless不对称二羟基化被用作构建C19-26亚片段的关键步骤。最后，通过利用羟醛偶联反应连接这两个单元，以良好的产率产生目标C7-26片段。
A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.