Total Synthesis of (±)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone
Total Synthesis of (±)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone
复制标题
DOI：
10.5012/bkcs.2010.31.11.3382
复制
发表时间：
2010-11-20
影响因子：
1.7
通讯作者：
Cho, Cheon-Gyu
中科院分区：
文献类型：
--
作者：
Cho, Hyun-Kyu;Tam, Nguyen Thanh;Cho, Cheon-Gyu
以3-乙基-5-溴-2-吡喃酮和乙烯基硫醚为起始原料，通过共轭加成-烷基化反应合成了（+/-）-螺精脒。
A new synthetic route to (+/-)-aspidospermidine was devised, starting from the cycloadduct of 3-ethyl-5-bromo-2-pyrone with vinyl sulfide through a tandem conjugate addition-alkylation sequence The requisite 3-ethyl-5-bromo-2-pyrone was prepared via the C3-selective Pd-catalyzed coupling reaction with Et3Al-dimethylaminoethanol complex