Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors.
Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors.
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DOI：
10.1016/j.cytogfr.2022.08.004
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发表时间：
2023-02
影响因子：
13
通讯作者：
Li, Shulin
中科院分区：
文献类型：
--
作者：
Zhang, Sheng;Rao, Ganesh;Heimberger, Amy;Li, Shulin
脑肿瘤是癌症相关死亡的 10 大主要原因之一，由于其关键位置、遗传异质性和血脑屏障，带来了独特的治疗挑战。靶向免疫疗法和免疫检查点阻断疗法的最新进展为脑肿瘤提供了替代治疗策略。纤维蛋白原样蛋白 2 (FGL2) 是一种 II 型膜蛋白，在宿主免疫细胞和肿瘤细胞中高度表达，可诱导低级别胶质瘤向高级别胶质母细胞瘤的转化。研究发现多种形式的 FGL2 蛋白在诱导肿瘤细胞免疫耐受和避免免疫监视方面具有广泛的作用。值得注意的是，FGL2 的存在通过促进 Treg、巨噬细胞以及可能的干细胞性，将低级别脑肿瘤转化为高级别脑肿瘤。肿瘤细胞（而非宿主细胞）中 FGL2 的缺失（敲除）会诱导 CD103 DC 细胞，从而触发肿瘤特异性 CD8+T 细胞活性，从而抑制脑肿瘤进展。针对 FGL2 的免疫疗法在改善小鼠模型的生存时间方面显示出巨大的前景。在本文中，我们将总结FGL2在免疫细胞和肿瘤细胞中的生物学功能。
Brain tumors are among the 10 leading causes of cancer-related death and present unique treatment challenges due to their critical location and genetic heterogeneity and the blood-brain barrier. Recent advances in targeted immunotherapy and immune checkpoint blocking therapy provide alternative therapeutic strategies for brain tumors. Fibrinogen-like protein 2 (FGL2), which induces transformation from low-grade glioma to high-grade glioblastoma, is a type II membrane protein that is highly expressed in both host immune cells and tumor cells. Studies have uncovered multiple forms of FGL2 proteins with a broad range of roles in inducing immune tolerance and avoiding immune surveillance in tumor cells. Of note, presence of FGL2 transforms low grade to high grade brain tumors via promoting Treg, macrophages, and perhaps stemness. Absence (knockout) FGL2 in tumor cells (not in host cells) induces CD103 DC cells, which triggers tumor specific CD8+T cell activity to reject brain tumor progression. Immunotherapies targeting FGL2 have shown great promise in improving survival time in murine models. In this article, we will summarize the biological function of FGL2 in immune and tumor cells.
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影响因子：
16.1
作者：
Lyon JG;Mokarram N;Saxena T;Carroll SL;Bellamkonda RV
通讯作者：
Bellamkonda RV
影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
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3.7
作者：
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通讯作者：
Wang Z
影响因子：
4.4
作者：
Chan, CWY;Chan, MWC;Levy, GA
通讯作者：
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影响因子：
15.9
作者：
Marsden, PA;Ning, Q;Levy, GA
通讯作者：
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