IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
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IL3 rs40401 多态性和吸烟与日本女性哮喘风险的相互作用：九州冲绳母婴健康研究。
DOI：
10.1111/sji.12171
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Arakawa M.
中科院分区：
文献类型：
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作者：
Miyake Y;Tanaka K;Arakawa M.
此前在韩国和中国进行的三项遗传关联研究调查了IL 3单核苷酸多态性（SNP）rs 40401与哮喘之间的关系，但结果不一致。我们研究了这种关系和IL 3SNP rs 40401与年轻成年日本女性吸烟之间相互作用的可能性。包括89名符合欧洲共同体呼吸健康调查（ECRHS）哮喘标准的妇女。对照受试者为700名根据ECRHS标准无哮喘的妇女，这些妇女未被医生诊断为哮喘和/或过敏性鼻炎，和/或不符合儿童哮喘和过敏性鼻炎国际研究的鼻结膜炎标准。以TT基因型为参照，在加性模型下，SNP rs 40401与哮喘发病风险显著正相关：校正比值比为1.39（95%CI：1.004-1.93）。在任何其他遗传模型中，这种正相关性都没有统计学意义。与从不吸烟的SNP rs 40401 TT或TC基因型受试者相比，曾吸烟的CC基因型受试者患哮喘的风险显著增加：校正OR为2.67（95%CI：1.23-5.79）;累加交互作用而非乘法交互作用显著。这项研究表明，IL 3SNP rs 40401与日本年轻成年女性的哮喘风险显著相关，并揭示了曾经吸烟和IL 3SNP rs 40401 CC基因型的组合与哮喘显著正相关。
Three previous genetic association studies conducted in Korea and China investigated the relationship betweenIL3single nucleotide polymorphism (SNP) rs40401 and asthma, but their results were inconsistent. We examined this relationship and the possibility of an interaction betweenIL3SNP rs40401 and smoking in young adult Japanese women. Included were 89 women who met the criteria of the European Community Respiratory Health Survey (ECRHS) for asthma. Control subjects were 700 women without asthma according to the ECRHS criteria who had not been diagnosed with asthma and/or allergic rhinitis by a doctor and/or who had not met the criteria of the International Study of Asthma and Allergies in Childhood for rhinoconjunctivitis. A significant positive association was found between SNP rs40401 and the risk of asthma, with the TT genotype as the reference under the additive model: the adjusted odds ratio was 1.39 (95% CI: 1.004–1.93). The positive association was not statistically significant in any other genetic model. Compared with subjects with the TT or TC genotype of SNP rs40401 who had never smoked, those with the CC genotype who had ever smoked had a significantly increased risk of asthma: the adjusted OR was 2.67 (95% CI: 1.23–5.79); the additive interaction, but not the multiplicative interaction, was significant. This study suggests thatIL3SNP rs40401 is significantly associated with the risk of asthma in young adult Japanese women and reveals that the combination of ever smoking and having the CC genotype ofIL3SNP rs40401 is significantly positively associated with asthma.