DNA alkylation by leinamycin can be triggered by cyanide and phosphines.
DNA alkylation by leinamycin can be triggered by cyanide and phosphines.
复制标题
氰化物和膦可以引发莱纳霉素的 DNA 烷基化作用。
DOI：
10.1016/s0960-894x(01)00196-2
复制
发表时间：
2001
影响因子：
2.7
通讯作者：
Gates,KS
中科院分区：
文献类型：
--
作者：
Zang,H;Breydo,L;Mitra,K;Dannaldson,J;Gates,KS
先前的研究表明，抗生素与硫醇的反应可增强抗肿瘤剂莱那霉素 (1) 对 DNA 的烷基化作用。此处，研究表明其他软亲核试剂（例如氰化物和膦）也可以引发莱纳霉素的 DNA 烷基化。总体而言，结果表明氰化物和膦与莱那霉素的反应会产生氧硫杂环酮中间体 (2)，已知该中间体会重排为 DNA 烷基化表锍离子 4。
Previous work has shown that alkylation of DNA by the antitumor agent leinamycin (1) is potentiated by reaction of the antibiotic with thiols. Here, it is shown that other soft nucleophiles such as cyanide and phosphines can also trigger DNA alkylation by leinamycin. Overall, the results suggest that reactions of cyanide and phosphines with leinamycin produce the oxathiolanone intermediate (2), which is known to undergo rearrangement to the DNA-alkylating episulfonium ion 4.