Gender effects in relapsing-remitting multiple sclerosis: Correlation between clinical variables and gene expression molecular pathways
Gender effects in relapsing-remitting multiple sclerosis: Correlation between clinical variables and gene expression molecular pathways
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DOI：
10.1016/j.jns.2009.06.038
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发表时间：
2009-11-15
影响因子：
4.4
通讯作者：
Gurevich, M.
中科院分区：
文献类型：
--
作者：
Achiron, A.;Gurevich, M.
对复发缓解型多发性硬化症 (RRMS) 患者的基因表达谱进行评估，以确定性别影响。在疾病晚期（> 40岁）的患者中，第二次复发的时间和 EDSS = 6.0 进展的时间存在明显的性别差异，并且在女性 RRMS 患者中发生得更快。已确定的分子生物学机制与免疫激活增加有关，而免疫激活增加与细胞凋亡的显着抑制相关，细胞凋亡增强了炎症过程，并且在女性 RRMS 患者中尤为明显。我们的研究结果为探索性别依赖性免疫调节治疗提供了可能性，这些治疗将基于基因表达机制，从而确定男性和女性 RRMS 患者之间的差异。 (C) 2009 Elsevier B.V. 保留所有权利。
Gene expression profiles were assessed in patients with relapsing-remitting multiple sclerosis (RRMS) to identify gender effects. Clear gender differences in time to second relapse and time to EDSS = 6.0 progression in patients with late onset of the disease (>40 years) were evident, and occurred more rapidly in female RRMS patients. Identified molecular biological mechanisms were related to increased immune activation associated with prominent inhibition of apoptosis that enhanced inflammatory processes and were move evident in female RRMS patients. Our findings open possibilities to explore gender-dependent immunomodulatory treatments that will be based on gene expression mechanisms that set the difference between male and female RRMS patients. (C) 2009 Elsevier B.V. All rights reserved.