βδ T Cells Are Not Essential for Control of Cutaneous Leishmania major Infection in Genetically Resistant C57BL/6 Mice
βδ T Cells Are Not Essential for Control of Cutaneous Leishmania major Infection in Genetically Resistant C57BL/6 Mice
复制标题
ββ T 细胞对于控制遗传抗性 C57BL/6 小鼠的皮肤利什曼原虫主要感染不是必需的
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. David
中科院分区：
文献类型：
--
作者：
A. Satoskar;M. Okano;J. David
由于γ δ T细胞被认为参与针对硕大利什曼原虫的宿主防御，因此研究了γ δ T细胞在针对该寄生虫的免疫中的作用。菌增长在α（T细胞受体[TCR] α-/-）和γ δ（TCR δ-/-）TCR缺陷的C57 BL/6小鼠中测量主要生长，并与对照（C57 BL/6）小鼠中的生长进行比较。而TCR α-/-小鼠在L.主要感染，TCR δ-/-和C57 BL/6小鼠有效地控制了感染。在体外刺激后，C57 BL/6小鼠的淋巴结细胞在感染的早期和晚期产生的干扰素（IFN）-γ明显多于TCR δ-/-小鼠;然而，两者在感染后第6周产生的IFN-γ水平相似。仅在感染后第2周，TCR delta -/-和C57 BL/6小鼠的培养物上清液均含有白细胞介素-4。这些结果表明γ δ CD 3 T细胞对于介导抗皮肤L. C57 BL/6小鼠中的主要感染。
As gammadelta T cells are believed to be involved in host defense against Leishmania major, the role of gammadelta T cells in immunity against this parasite was investigated. The growth of L. major was measured in alphabeta (T cell receptor [TCR] alpha -/-) and gammadelta (TCR delta -/-) TCR-deficient C57BL/6 mice and compared with growth in control (C57BL/6) mice. While TCR alpha -/- mice developed nonhealing lesions containing large numbers of parasites following L. major infection, TCR delta -/- and C57BL/6 mice effectively controlled the infection. Following in vitro stimulation, lymph node cells from C57BL/6 mice produced significantly more interferon (IFN)-gamma than those from TCR delta -/- mice during early and late phases of infection; however, both produced similar levels of IFN-gamma at postinfection week 6. Culture supernatants from both TCR delta -/- and C57BL/6 mice contained interleukin-4, at postinfection week 2 only. These results indicate that gammadelta CD3 T cells are not essential for mediating protection against cutaneous L. major infection in C57BL/6 mice.
人类利什曼病中的抗原反应性 γ δ T 细胞。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Russo,DM;Armitage,RJ;Barral-Netto,M;Barral,A;Grabstein,KH;Reed,SG
通讯作者：
Reed,SG