The 2019 FASEB Science Research Conference on Matricellular Proteins in Inflammation and Tissue Remodeling, July 14-19, 2019, Lisbon, Portugal.
The 2019 FASEB Science Research Conference on Matricellular Proteins in Inflammation and Tissue Remodeling, July 14-19, 2019, Lisbon, Portugal.
复制标题
2019 年 FASEB 炎症和组织重塑基质细胞蛋白科学研究会议，2019 年 7 月 14-19 日，葡萄牙里斯本。
DOI：
10.1096/fj.202000364
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Murphy-Ullrich,Joanne
中科院分区：
文献类型：
--
作者：
Stenina-Adognravi,Olga;Murphy-Ullrich,Joanne
作为FASEB科学研究会议系列的一部分，“炎症和组织重塑中的基质细胞蛋白质”会议延续了20多年来致力于基质细胞蛋白质的会议历史。基质细胞蛋白是由Paul Bornstein在1995年定义的一个结构多样的、模块化的分泌蛋白家族，其结合细胞外基质分子和细胞受体以调节广泛的关键细胞过程，包括细胞粘附、迁移、存活、增殖、细胞外基质组织、生长因子和蛋白酶调节以及分化。重要的是新兴的数据显示了基质细胞蛋白在疾病中的关键作用，通过它们在调节组织重塑、血管生成、纤维化、炎症、免疫、代谢和发育中的作用。基质细胞蛋白是多种疾病的治疗靶标，包括心血管疾病、癌症和转移、自身免疫、神经发生和神经性疼痛、眼部疾病（包括炎症、青光眼和黄斑变性）、糖尿病和糖尿病并发症、骨骼发育不良和再生以及关节炎。该领域已经从阐明这些复杂蛋白质的结构、功能和活性发展到确定其在疾病中的作用和开发基质细胞靶向治疗干预。
The conference “Matricellular Proteins in Inflammation and Tissue Remodeling, presented as part of the FASEB Scientific Research Conference series, continues a more than 20-year history of conferences dedicated to matricellular proteins. Matricellular proteins were defined by Paul Bornstein in 1995 as a family of structurally diverse, modular secreted proteins that bind to both extracellular matrix molecules and cellular receptors to regulate a wide array of key cellular processes, including cell adhesion, migration, survival, proliferation, extracellular matrix organization, growth factor and protease regulation, and differentiation. Of importance are emerging data showing key roles for matricellular proteins in diseases through their roles in regulating tissue remodeling, angiogenesis, fibrosis, inflammation, immunity, metabolism, and development. Matricellular proteins are therapeutic targets for multiple diseases, including cardiovascular disease, cancer and metastasis, autoimmunity, neurogenesis and neuropathic pain, ocular diseases including inflammation, glaucoma, and macular degeneration, diabetes and diabetic complications, skeletal dysplasia and regeneration, and arthritis. The field has evolved from elucidating structure function activities of these complex proteins to identifying roles in diseases and the development of matricellular-targeted therapeutic interventions.