Paramutation in maize: RNA mediated trans-generational gene silencing.
Paramutation in maize: RNA mediated trans-generational gene silencing.
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DOI:
10.1016/j.gde.2010.01.008
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发表时间:
2010-04
影响因子:
4
通讯作者:
Chandler, Vicki Lynn
中科院分区:
文献类型:
--
作者:
Arteaga-Vazquez, Mario Alberto;Chandler, Vicki Lynn
Paramutation involves trans interactions between alleles or homologous sequences that establish distinct gene expression states that are heritable for generations. It was first described in maize by Alexander Brink in the 1950's, with his studies of the r1 (red1) locus. Since that time, paramutation-like phenomena have been reported in other maize genes, other plants, fungi and animals. Paramutation can occur between endogenous genes, two transgenes or an endogenous gene and transgene. Recent results indicate that paramutation involves RNA-mediated heritable chromatin changes and a number of genes implicated in RNAi pathways. However, not all aspects of paramutation can be explained by known mechanisms of RNAi-mediated transcriptional silencing.
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