Alcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis
Alcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis
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DOI：
10.1007/s00038-009-0095-x
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发表时间：
2010-06-01
影响因子：
4.6
通讯作者：
Shuper, Paul
中科院分区：
文献类型：
--
作者：
Baliunas, Dolly;Rehm, Juergen;Shuper, Paul
分析饮酒与艾滋病病毒感染的关系。入选标准为：HIV感染事件、饮酒史以及两者之间的相关性。使用DerSimonian和Laird随机效应模型。对于具有给定类型的多个估计值的研究，使用逆方差加权法合并估计值。使用Begg和Egger检验评估发表偏倚。采用Q和I（2）统计法评估异质性，共纳入10项研究。总体饮酒量（确定的三种类型中的任何一种）增加了HIV的风险（RR 1.98，95% CI 1.59-2.47）。饮酒者的风险高出77%（RR 1.77，95% CI 1.43-2.19）。那些在发生性关系之前或发生性关系时饮酒的人的风险增加了87%（RR 1.87，95%CI 1.39-2.50）。酗酒者的风险是非酗酒者的两倍（RR 2.20，95%CI 1.29-3.74）。饮酒与HIV感染的风险增加有关。需要进行更多的研究，以进一步调查可能的因果关系。
To analyze the relationship between alcohol consumption and incident HIV infection.Articles were identified via electronic and hand searches. Inclusion criteria were: incident HIV infection, preceding alcohol consumption, and association relating the two. The DerSimonian and Laird random effects model was used. For studies with more than one estimate of a given type, estimates were combined using the inverse variance weighted method. Publication bias was assessed using Begg's and Egger's tests. Heterogeneity was assessed using Q and I (2) statistics.Ten studies were included. Overall alcohol consumption (any of the three types identified) increased the risk of HIV (RR 1.98, 95% CI 1.59-2.47). Alcohol consumers were at 77% higher risk (RR 1.77, 95% CI 1.43-2.19). Those consuming alcohol prior to, or at the time of, sexual relations were at an 87% increased risk (RR 1.87, 95% CI 1.39-2.50). For binge drinkers, the risk was double that of non-binge drinkers (RR 2.20, 95% CI 1.29-3.74).Alcohol consumption is associated with an increased risk of incident HIV infection. Additional research is required to further investigate a possible causal role.