Mild moxibustion for Irritable Bowel Syndrome with Diarrhea (IBS-D): A randomized controlled trial
Mild moxibustion for Irritable Bowel Syndrome with Diarrhea (IBS-D): A randomized controlled trial
复制标题
温和艾灸治疗腹泻性肠易激综合征（IBS-D）：一项随机对照试验
DOI：
10.1016/j.jep.2022.115064
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发表时间：
2022
影响因子：
5.4
通讯作者：
Huangan Wu
中科院分区：
文献类型：
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作者：
Zhaoqin Wang;Manwen Xu;Zheng Shi;Chunhui Bao;Huirong Liu;Cili Zhou;Yilu Yan;Chunye Wang;Guona Li;Wei Zhang;Anqi Gao;Huangan Wu
民族药理学相关性艾灸疗法是中医外治方法之一，是将艾草粉碎干燥而成。 & Vanio，将其卷成香烟状的长条，点燃，利用其温热刺激特定穴位一定时间。在亚洲，它经常用于治疗各种疾病，尤其是腹痛。临床报告表明，针灸是治疗腹泻性肠易激综合征（IBS-D）的有效方法。然而，目前还没有安慰剂对照研究证明其安全性和有效性。 目的通过与安慰剂灸的比较，评价温和灸（MM）治疗腹泻型肠易激综合征（IBS-D）的效果。 患者和方法 这是一项单中心、随机对照试验，在中国上海针灸经络研究所进行，入组了 76 名符合 IBS-D 罗马 IV 诊断标准的受试者。 2017 年和 2019 年 12 月。76 名参与者按 1:1 的比例随机分配到轻度艾灸组 (MM) 或安慰剂艾灸组 (PM)。在 6 周的时间内实施了 18 次 MM 或 PM 课程（每周 3 次）。主要结局是治疗 6 周后症状得到充分缓解。 结果 76 例 IBS-D 患者被随机分组（MM 组 38 例，PM 组 38 例）被纳入意向治疗 (ITT) 分析组。治疗第6周后，MM组的有效率显着高于PM组（81.58% vs. 36.84%），估计差异为44.74（95% CI，23.46至66.02，P<0.001）。没有参与者报告严重不良反应。结论研究结果表明温和灸治疗IBS-D可能比安慰剂灸更有效，效果可持续长达12周。试验注册ChiCTR，ChiCTR2100046852。 2021年5月29日注册——追溯注册，网址：http://www.chictr.org.cn/showproj.aspx?proj=127000。
Ethnopharmacological relevanceMoxibustion therapy is one of the traditional Chinese medicine external treatment methods, which involves crushing dried herbArtemisia argyi H. Lév. & Vanioand rolling it into a long cigarette-like strip, igniting it and using its warmth to stimulate specific acupuncture points for a certain period of time. It is often used in Asia to treat various diseases, especially abdominal pain. Clinical reports suggest that acupuncture and moxibustion are the effective treatment for Irritable Bowel Syndrome with Diarrhea (IBS-D). However, there is no placebo-controlled study to prove its safety and efficacy.ObjectiveTo evaluate the effects of mild moxibustion (MM) for the treatment of irritable bowel syndrome with diarrhea (IBS-D) through comparisons with those of placebo moxibustion.Patients and methodsThis was a single-site, randomized controlled trial was conducted at Shanghai Research Institute of Acupuncture and Meridian in China and enrolled 76 participants who met the Rome IV diagnostic criteria for IBS-D between May 2017 and December 2019. 76 participants were randomized to either mild moxibustion (MM) or placebo moxibustion group (PM) in a 1:1 ratio. 18 sessions of MM or PM were implemented over the course of 6 weeks (3 times per week). The primary outcome was adequate relief after 6 weeks of treatment.ResultsOf 76 patients with IBS-D who were randomized (38 in the MM group and 38 in the PM group) were included in the intention-to-treat (ITT) analysis set. After treatment at week 6, the response rate was significantly higher in the MM group than the PM group (81.58% vs. 36.84%) with an estimated difference of 44.74 (95% CI, 23.46 to 66.02,P< 0.001). No participant reported severe adverse effects.ConclusionThe findings suggest that mild moxibustion may be more effective than placebo moxibustion for the treatment of IBS-D, with effects lasting up to 12 weeks.Trial registrationChiCTR, ChiCTR2100046852. Registered 29 May 2021 - Retrospectively registered, URL: http://www.chictr.org.cn/showproj.aspx?proj=127000.