THE SEQUENTIAL HYPOTHESIS ON SLEEP FUNCTION .1. EVIDENCE THAT THE STRUCTURE OF SLEEP DEPENDS ON THE NATURE OF THE PREVIOUS WAKING EXPERIENCE
THE SEQUENTIAL HYPOTHESIS ON SLEEP FUNCTION .1. EVIDENCE THAT THE STRUCTURE OF SLEEP DEPENDS ON THE NATURE OF THE PREVIOUS WAKING EXPERIENCE
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DOI：
10.1016/0031-9384(88)90196-5
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发表时间：
1988-01-01
影响因子：
2.9
通讯作者：
GIUDITTA, A
中科院分区：
文献类型：
--
作者：
AMBROSINI, MV;SADILE, AG;GIUDITTA, A
关于睡眠功能的顺序假说认为，大脑在清醒期间收集的信息在睡眠期间分两个主要步骤进行处理，发生在同步睡眠(SS)期间和最终发生在异相睡眠(PS)期间。为了验证这一假说的主要结果，即(1)SS参与大脑信息处理；以及(2)睡眠结构取决于先前清醒经历的性质，设计了一项实验，包括暴露于训练课程(双向主动回避)但学习失败(NL)的大鼠，以及留在同一训练室的家中笼子里的大鼠(C)。NL组大鼠在习得后3小时(3小时)的睡眠结构与C组大鼠不同，主要是因为前者SS发作时间明显延长。一项更详细的分析表明，在NL大鼠中，不跟随PS的SS发作首先增加了它们的持续时间，而跟随PS的SS发作在睡眠的后半部分变得更长。在氯丙咪嗪治疗的获取期末去除PS的NL和C亚组的比较中，获得了可比的结果。这些数据支持序贯假说，并为SS在大脑信息处理中的主要作用提供了证据。
The sequential hypothesis on sleep function assumes that the information gathered by brain during the waking period is processed during sleep in two main steps occurring during synchronized sleep (SS) and, eventually, during paradoxical sleep (PS). To verify the main consequences of the hypothesis, i.e., (1) that SS is involved in brain information processing; and (2) that the structure of sleep is dependent on the nature of the previous waking experience, an experiment was designed involving rats exposed to a training session (two-way active avoidance) but failing to learn (NL), and rats left in their home cages in the same training room (C). The structure of sleep, determined by EEG techniques in the postacquisition period (3 hr), was different in NL rats in comparison to C rats, chiefly because SS episodes were markedly longer in the former group. A more detailed analysis indicated that, in NL rats, SS episodes not followed by PS increased their duration first, while those followed by PS became longer in the second half of the sleep period. Comparable results were obtained in the comparison of NL and C subgroups deprived of PS at the end of the acquisition period by chlomipramine treatment. The data support the sequential hypothesis and provide evidence for a primary role of SS in brain information processing.