Canadian Cohort Obstructive Lung Disease (CanCOLD): Fulfilling the Need for Longitudinal Observational Studies in COPD
Canadian Cohort Obstructive Lung Disease (CanCOLD): Fulfilling the Need for Longitudinal Observational Studies in COPD
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DOI：
10.3109/15412555.2012.665520
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发表时间：
2014-04-01
影响因子：
2.2
通讯作者：
Sin, Don D.
中科院分区：
文献类型：
--
作者：
Bourbeau, Jean;Tan, Wan C.;Sin, Don D.
与其他主要死亡原因相比，对慢性阻塞性肺病的认识、诊断和治疗仍然太低。本文描述了加拿大慢性阻塞性肺疾病（canold）研究的方案目标、设计和方法，这是一项流行病学和综合研究。CanCOLD研究旨在更好地了解COPD表现和疾病进展的异质性。我们假设，具有不利COPD“表型”的个体和具有不健康生活习惯、环境/工作暴露或共病的高危受试者（曾经吸烟者）将增加肺功能下降的风险，而这与他们的累积吸烟暴露无关。该研究是一项前瞻性多中心队列研究（6个省9个地点），以加拿大COPD患病率研究“COLD”为基础。该研究计划包括1800名至少40岁的受试者，他们从普通人群中抽样，并被发现分为4组：1)COPD中重度（GOLD 2-4）；2)轻度COPD (GOLD 1)；3)有危险的受试者（曾经吸烟）；4)不吸烟的受试者没有气流阻塞。数据收集采用严格标准化的方法，包括问卷调查、肺功能和心肺运动测试、CT扫描和血液采样。CanCOLD是一项独特的研究，将解决COPD疾病演变和疾病管理方面具有挑战性和重要的研究问题，并将有助于确定COPD风险个体和轻度疾病的COPD患者的COPD疾病演变的自然史。
Awareness, diagnosis and treatment of COPD, compared to other major causes of death, remains far too low. This article describes the protocol objectives, design and the approaches taken in the Canadian Chronic Obstructive Lung Disease (CanCOLD) study, an epidemiological and integrated research. The CanCOLD study aims at better understanding heterogeneity of COPD presentation and disease progression. We hypothesize that individuals with unfavourable COPD "phenotypes" and subjects at-risk (ever smokers) with unhealthy lifestyle habits, environmental/work exposure, or co-morbidities will have increased risk of lung function decline independent of their cumulative exposure to cigarette smoke. The study is a prospective multi-center cohort study (9 sites in 6 provinces) built on the Canadian COPD prevalence study "COLD." The study plan is to include 1800 subjects at least 40 years old who were sampled from the general population and who were found to fall within 4 groups: 1) COPD moderate-severe (GOLD 2-4); 2) COPD mild (GOLD 1); 3) subjects at-risk (ever smoker); and, 4) subjects never-smoker free of airflow obstruction. Data collection is based on using strictly standardized methods involving questionnaires, pulmonary function and cardiorespiratory exercise tests, CT scans, and blood sampling. CanCOLD is a unique study that will address challenging and important research questions on COPD disease evolution and disease management and will help to define the natural history of COPD disease evolution in individuals at-risk for COPD and in those with COPD who have mild disease.