Self-awareness of deficits in Parkinson disease
Self-awareness of deficits in Parkinson disease
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DOI：
10.1080/1385404049052412
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发表时间：
2004-08-01
影响因子：
3.9
通讯作者：
Bowers, D
中科院分区：
文献类型：
--
作者：
Leritz, E;Loftis, C;Bowers, D
病感失认症是一种对缺陷的无意识或否认。虽然它主要与皮质脑区域的损伤有关，但在皮质下脑疾病患者中也有病感失认的报道，本研究调查了病感失认是否是帕金森病的一个特征。48名主要为左侧（N = 16）或右侧（N = 32）运动症状的帕金森病患者最终接受了右侧或左侧苍白球切开术，48名被确定为护理人员的患者完成了评估PD严重程度的问卷。在苍白球切开术侧，患者和照顾者之间的报告没有差异。然而，作为一个群体，患者认为自己在2项日常生活活动指标上的受损程度明显较低，这表明基底神经节功能障碍可能会改变对疾病严重程度的认识。左侧症状PD组的患者和照顾者在选择的功能独立性指标上存在显著差异。这表明了偏侧性和利手性的潜在相互作用。强调了未来在PD患者中进行更严重认知障碍研究的重要性。
Anosognosia is an unawareness or denial of deficits. While it has mainly been associated with damage to cortical brain regions, anosognosia has also been reported in patients with subcortical brain disease, The present study investigated whether anosognosia is a feature of Parkinson disease. Forty-eight Parkinson disease patients with predominantly left- (N = 16) or right-sided (N = 32) motor symptoms who eventually underwent right or left pallidotomies, and 48 individuals identified as caregivers completed questionnaires rating severity of PD. There was no discrepancy in report between patients and caregivers as a function of pallidotomy side. However, as a group, patients rated themselves as significantly less impaired on 2 measures of activities of daily living, indicating that basal ganglia dysfunction may alter insight into severity of illness. Patients and caregivers in the left-symptom PD group differed significantly on selected measures of functional independence. This suggests the potential interaction of laterality and handedness. The importance of future investigations in PD patients with more severe cognitive impairment is stressed.