New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity.
New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity.
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格氏恩格尔酵母培养物中的新二萜及其 CETP 抑制活性
DOI：
10.1007/s13659-015-0055-5
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发表时间：
2015-04-08
影响因子：
4.7
通讯作者：
Liu JK
中科院分区：
文献类型：
--
作者：
Wang Y;Zhang L;Wang F;Li ZH;Dong ZJ;Liu JK
从真菌隐孔菌（Engleromyces goetzii）的培养物中分离得到一种新的闭花木烷型二萜，命名为隐孔菌酸A（1），一种新的蔷薇烷型二萜，命名为隐孔菌酸B（2）以及一种新的天然蔷薇烷型二萜隐孔菌醇（3），同时还有三种已知的蔷薇烷型二萜，玫红内酯（4）、玫瑰酮内酯（5）和7 - 脱氧玫瑰酮内酯（6），该真菌自然生长在高山竹茎上。基于光谱数据对新化合物进行了结构解析。此外，对化合物1 - 6的胆固醇酯转移蛋白（CETP）抑制活性进行了评估。本文报道了这些化合物的分离、结构解析以及CETP抑制活性。
本文的网络版（doi:10.1007/s13659 - 2015 - 0055 - 5）包含补充材料，授权用户可获取。
One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.