ANTITHROMBIN-III - STRUCTURAL AND FUNCTIONAL-ASPECTS
ANTITHROMBIN-III - STRUCTURAL AND FUNCTIONAL-ASPECTS
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DOI：
10.1016/0300-9084(90)90123-x
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发表时间：
1990-08-01
期刊：
影响因子：
3.9
通讯作者：
MORAS, D
中科院分区：
文献类型：
--
作者：
MOUREY, L;SAMAMA, JP;MORAS, D
抗凝血酶III是一种血浆糖蛋白，负责凝血级联中的凝血酶抑制。其裂解形式的X射线结构已被确定并精确到3.2埃。分辨率总体拓扑结构与丝氨酸蛋白酶抑制剂（serpin）（丝氨酸蛋白酶抑制剂）超家族的另一个成员α 1-抗胰蛋白酶相似。抗凝血酶III的生物活性由多糖肝素介导。描述了该效应器的结合位点。一个可能的结构过渡从本机的裂解结构进行了讨论。
Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 .ANG. resolution. The overall topology is similar to that of .alpha.1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.