Retinal Pigment Epithelium Atrophy in Recessive Stargardt Disease as Measured by Short-Wavelength and Near-Infrared Autofluorescence.
Retinal Pigment Epithelium Atrophy in Recessive Stargardt Disease as Measured by Short-Wavelength and Near-Infrared Autofluorescence.
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DOI：
10.1167/tvst.10.1.3
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发表时间：
2021-01
影响因子：
3
通讯作者：
Sparrow JR
中科院分区：
文献类型：
--
作者：
Jauregui R;Nuzbrokh Y;Su PY;Zernant J;Allikmets R;Tsang SH;Sparrow JR
目的比较Stargardt病(STGD)患者视网膜色素上皮(RPE)短波(SW-AF)和近红外自发荧光(NIR-AF)图像的检测结果。由两个独立的评分员对来自115名患者的115只眼的短波-房颤和近红外-房颤图像进行分析。测量代表视网膜色素上皮萎缩的弱自身荧光区，并对两种模式进行比较。患者被分成四组：新生(6[5%])、广泛(21[18%])、离散(55[48%])和脉络膜视网膜萎缩(33[29%])。近红外线房颤的低房颤面积(3.9mm2比2.2mm2，P&t；0.001)和脉络膜视网膜萎缩的面积(12.7mm2比11.4mm2，P=0.015)明显大于短波房颤。在新生和广泛性萎缩患者中也观察到了类似的定性结果。使用面积线性模型，在离散性萎缩(0.20vs.0.32mm2/y，P=0.275)和脉络膜视网膜萎缩(1.30vs.1.74mm2/y，P=0.671)的短波-房颤和近红外-房颤图像中，病变面积增加的速度相似。使用半径线性模型，离散(0.03vs.0.05mm2/y，P=0.221)和脉络膜视网膜萎缩(0.08vs.0.10mm2/y，P=0.754)患者的短波-房颤和近红外-房颤图像上的病变有效半径也有类似的增加。与SW-AF图像相比，NIR-AF显示STGD1患者的RPE萎缩面积更大，但两种模式的病变扩大率相似。通过房颤成像测量RPE萎缩对于监测STGD1疾病进展至关重要，鉴于我们的研究结果，我们建议患者更多地使用NIR-AF。
To compare the detection of retinal pigment epithelium (RPE) atrophy in short-wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images in Stargardt disease (STGD1) patients. SW-AF and NIR-AF images (115 eyes from 115 patients) were analyzed by two independent graders. Hypoautofluorescent (hypoAF) areas, indicative of RPE atrophy, were measured, and the two modalities were compared. Patients were segregated into four groups: nascent (6 [5%]), widespread (21 [18%]), discrete (55 [48%]), and chorioretinal atrophy (33 [29%]). The areas of hypoAF were larger in NIR-AF compared to SW-AF images in discrete (3.9 vs. 2.2 mm2, P < 0.001) and chorioretinal atrophy (12.7 vs. 11.4 mm2, P = 0.015). Similar findings were observed qualitatively in nascent and widespread atrophy patients. Using the area linear model (ALM), lesion area increased at similar rates in SW-AF and NIR-AF images of discrete atrophy (0.20 vs. 0.32 mm2/y, P = 0.275) and chorioretinal atrophy (1.30 vs. 1.74 mm2/y, P = 0.671). Using the radius linear model (RLM), the lesion effective radius also increased similarly in SW-AF and NIR-AF images in discrete (0.03 vs. 0.05 mm2/y, P = 0.221) and chorioretinal atrophy (0.08 vs. 0.10 mm2/y, P = 0.754) patients. NIR-AF reveals a larger area of RPE atrophy in STGD1 patients compared to SW-AF images, but rates of lesion enlargement in the two modalities are similar. Measurements of RPE atrophy by AF imaging are crucial for monitoring STGD1 disease progression and given our findings we advocate greater use of NIR-AF for patients.
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DOI：
10.1097/01.iae.0000433986.32991.1e
发表时间：
2014-03-01
影响因子：
3.3
作者：
Panthier, Christophe;Querques, Giuseppe;Souied, Eric H.
通讯作者：
Souied, Eric H.
影响因子：
4.4
作者：
Schmitz-Valckenberg, Steffen;Brinkmann, Christian K.;Holz, Frank G.
通讯作者：
Holz, Frank G.
影响因子：
4.4
作者：
Burke, Tomas R.;Duncker, Tobias;Delori, Francois C.
通讯作者：
Delori, Francois C.
影响因子：
4.2
作者：
Paavo M;Lee W;Allikmets R;Tsang S;Sparrow JR
通讯作者：
Sparrow JR
影响因子：
4.4
作者：
Duncker, Tobias;Marsiglia, Marcela;Sparrow, Janet R.
通讯作者：
Sparrow, Janet R.