Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites.
Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites.
复制标题
使用双读数的回波平面 J 分辨光谱成像：人脑代谢物的实施和定量。
DOI：
10.1038/s41598-017-03121-0
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发表时间：
2017
影响因子：
4.6
通讯作者：
Thomas,MAlbert
中科院分区：
文献类型：
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作者：
Sarma,ManojK;Nagarajan,Rajakumar;Iqbal,Zohaib;Macey,PaulM;Thomas,MAlbert
已经尝试使用回波平面（EP）读出梯度来减少多维J分辨光谱成像（JRESI）中的总扫描时间，但是采集持续时间仍然是脑中常规临床使用的限制。我们在这里提出了一个显着的加速实现了4D EP-JRESI序列，收集双相编码线在一个单一的重复时间（TR）内使用两个双极读出列车。使用3 T MRI/MRS扫描仪，在10名健康对照和脑体模中评价了这种新型4D序列（称为基于多回波的回波平面分辨光谱成像（ME-EP-JRESI））的性能和可靠性。先验知识拟合（ProFit）算法，与一个新的模拟基组组成的大分子和脂质除了代谢物的兴趣，用于定量。体模和体内数据均表明，ME-EP-JRESI序列的代谢物定位和空间/光谱分布与EP-JRESI序列的代谢物定位和空间/光谱分布具有良好的一致性。在枕叶和颞叶，生理浓度较高的代谢产物Glx（Glu+Gln）、tNAA（NAA+NAAG）、mI的变异系数均在9- 25%之间。总之，我们已经实施、验证和测试了ME-EP-JRESI序列，证明多回波采集可以成功缩短EP-JRESI序列的总扫描持续时间。
Attempts have been made to reduce the total scan time in multi-dimensionalJ-resolved spectroscopic imaging (JRESI) using an echo-planar (EP) readout gradient, but acquisition duration remains a limitation for routine clinical use in the brain. We present here a significant acceleration achieved with a 4D EP-JRESI sequence that collects dual phase encoded lines within a single repetition time (TR) using two bipolar read-out trains. The performance and reliability of this novel 4D sequence, called Multi-Echo based Echo-PlanarJ-resolved Spectroscopic Imaging (ME-EP-JRESI), was evaluated in 10 healthy controls and a brain phantom using a 3 T MRI/MRS scanner. The prior knowledge fitting (ProFit) algorithm, with a new simulated basis set consisting of macromolecules and lipids apart from metabolites of interest, was used for quantitation. Both phantom andin-vivodata demonstrated that localization and spatial/spectral profiles of metabolites from the ME-EP-JRESI sequence were in good agreement with that of the EP-JRESI sequence. Both in the occipital and temporal lobe, metabolites with higher physiological concentrations including Glx (Glu+Gln), tNAA (NAA+NAAG), mI all had coefficient of variations between 9–25%. In summary, we have implemented, validated and tested the ME-EP-JRESI sequence, demonstrating that multi-echo acquisition can successfully reduce the total scan duration for EP-JRESI sequences.