A New Strategy for the Synthesis of Poly-Substituted 3-H, 3-Fluoro, or 3-Trifluoromethyl Pyridines via the Tandem C-F Bond Cleavage Protocol
A New Strategy for the Synthesis of Poly-Substituted 3-H, 3-Fluoro, or 3-Trifluoromethyl Pyridines via the Tandem C-F Bond Cleavage Protocol
复制标题
通过串联 C-F 键断裂方案合成多取代 3-H、3-氟或 3-三氟甲基吡啶的新策略
DOI：
10.1021/ol101859p
复制
发表时间：
2010-10-01
期刊：
影响因子：
5.2
通讯作者：
Gong, Yuefa
中科院分区：
文献类型：
--
作者：
Chen, Zixian;Zhu, Jiangtao;Gong, Yuefa
介绍了一种基于阴离子活化的氟烷基C-F键断裂合成多取代3-H、3-F和3-三氟甲基吡啶的新策略。在无贵金属的条件下，以较高的产率合成了一系列2，6-二取代4-氨基吡啶，使该方法成为吡啶合成的一种补充。
A new strategy for the synthesis of poly-substituted 3-H, 3-F, and 3-trifluoromethyl pyridines based on C-F bond breaking of the anionically activated fluoroalkyl group is described. A series of 2,6-disubstituted 4-amino pyridines were prepared through this domino process in high yields under noble metal-free conditions, making this method a supplement to pyridine synthesis.