Plasma urotensin in human systolic heart failure
Plasma urotensin in human systolic heart failure
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DOI：
10.1161/01.cir.0000044388.19119.02
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发表时间：
2002-12-03
期刊：
影响因子：
37.8
通讯作者：
Davies, JE
中科院分区：
文献类型：
--
作者：
Ng, LL;Loke, I;Davies, JE
背景：人尿紧张素11 （UTN）具有强大的血管活性和心脏刺激作用，作用于G蛋白连接受体GPR14。心衰时心肌UTN表达上调，UTN刺激心肌利钠肽表达。我们研究了心力衰竭（HF；左心室收缩功能障碍）患者血浆UTN水平与血浆n端前脑利钠肽（N-BNP）水平的比较。方法和结果：126例HF患者和220例年龄和性别匹配的对照组血浆中n - bnp和UTN的测定。两种肽在HF患者血浆中均升高，且相关（r(s) =0.35, P < 0.001）。与N-BNP相比，血浆UTN与纽约心脏协会（NYHA）分级无相关性。尽管血浆N-BNP与年龄和女性性别呈正相关，但血浆UTN没有这种年龄依赖性变化，对照组女性的水平低于对照组男性。诊断HF的受试者工作特征曲线N-BNP和UTN的面积分别为0.90和0.86 （P < 0.001）。合并UTN诊断NYHA I型HF的受试者工作特征曲线面积优于合并N-BNP诊断。结论：HF患者血浆UTN升高，提示该肽具有病理生理作用。血浆UTN可能是诊断HF的有用替代N-BNP，因为其水平升高与年龄、性别或NYHA类别无关。
Background-Human urotensin 11 (UTN) has potent vasoactive and cardiostimulatory effects, acting on the G protein-linked receptor GPR14. Myocardial UTN expression is upregulated in heart failure, and UTN stimulates myocardial expression of the natriuretic peptides. We investigated plasma UTN levels in heart failure (HF; left ventricular systolic dysfunction) in comparison with plasma N-terminal pro-brain natriuretic peptide (N-BNP) levels.Methods and Results-N-BNP and UTN were measured in plasma from 126 patients with HF and 220 age- and sex-matched controls. Both peptides were elevated in plasma of HF patients and were correlated (r(s) =0.35, P < 0.001). In contrast to N-BNP, there was no relationship of plasma UTN with New York Heart Association (NYHA) class. Although plasma N-BNP showed a positive relationship with age and female sex, there was no such age-dependent change in plasma UTN, and control women had lower levels compared with control men. Receiver operating characteristic curves for the diagnosis of HF had areas of 0.90 and 0.86 for N-BNP and UTN, respectively (P < 0.001 for both). Receiver operating characteristic curve area for diagnosis of NYHA class I HF with UTN was better than that with N-BNP.Conclusions-Plasma UTN is elevated in HF, which suggests a pathophysiological role for this peptide. Plasma UTN may be a useful alternative to N-BNP in the diagnosis of HF, inasmuch as its levels are elevated irrespective of age, sex, or NYHA class.