One‐Pot Synthesis of Novel Branched Polylactide Through the Copolymerization of Lactide with Mevalonolactone
One‐Pot Synthesis of Novel Branched Polylactide Through the Copolymerization of Lactide with Mevalonolactone
复制标题
DOI：
10.1002/1521-3927(20010701)22:11
复制
发表时间：
2001-07
影响因子：
4.6
通讯作者：
F. Tasaka;Y. Ohya;T. Ouchi
中科院分区：
文献类型：
--
作者：
F. Tasaka;Y. Ohya;T. Ouchi
聚乳酸是一种免疫原性低、生物相容性好的可生物降解、可吸收的聚合物，目前主要用于生物医学领域的研究。支化聚合物由于其分子结构的不同，具有不同于线性聚合物的流变性和力学性能。我们合成了新型的可生物降解的聚乳酸，其支化结构仅由可代谢降解和/或可吸收的材料组成。支化聚乳酸是以代谢中间体dl-甲伐内酯为双官能团的双功能共聚单体，与L丙交酯一锅共聚得到的。支化聚乳酸的玻璃化转变点、熔点和结晶度均低于线型聚乳酸。
Polylactide, which is a biodegradable and bio-absorbable polymer having low immunogenicity and good biocompatibility, has been mainly studied for biomedical applications. Branched polymers have different rheological and mechanical properties compared with their linear counterparts owing to their molecular architectures. We synthesized novel biodegradable polylactide having a branched structure composed of metabolically degradable and/or absorbable materials only. The branched polylactide was obtained from a one-pot copolymerization of L-lactide using metabolic intermediate dl-mevalonolactone as a bifunctional comonomer having both lactone ring and pendant hydroxy group. The glass transition point, melting point and crystallinity of the branched polylactide are lower than those of linear polylactide.