Forty-five-year follow-up on the renal function after spinal cord injury
Forty-five-year follow-up on the renal function after spinal cord injury
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DOI：
10.1038/sc.2015.242
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发表时间：
2016-06-01
期刊：
影响因子：
2.2
通讯作者：
Biering-Sorensen, F.
中科院分区：
文献类型：
--
作者：
Elmelund, M.;Oturai, P. S.;Biering-Sorensen, F.
研究设计：回顾图表回顾。目的：调查脊髓损伤(SCI)患者肾脏恶化的程度，并确定与肾脏恶化相关的危险指标。地点：丹麦霍恩贝克RigshSpitalet脊髓损伤诊所。方法：本研究包括1956至1975年间收治的116例脊髓损伤患者。肾造影术和血铬-51-EDTA清除结果收集自受伤时至2012年的病历资料，并用累积发病曲线分析肾脏恶化的发生。结果：使用时间最长的膀胱排空方法依次为反射触发(63%)、膀胱显露(22%)、留置导尿管(5%)、正常排尿(4%)、回肠导管(3%)和清洁间歇导尿法(2%)。肾脏中度恶化的累积风险(肾造影或相对肾小球滤过率(GFR)中肾功能分布超过40%-60%)
Study design: Retrospective chart review.Objectives: To investigate the extent of renal deterioration in patients with spinal cord injury (SCI) and to identify risk indicators associated with renal deterioration.Setting: Clinic for Spinal Cord Injuries, Rigshospitalet, Hornbaek, Denmark.Methods: This study included 116 patients admitted to our clinic with a traumatic SCI sustained between 1956 and 1975. Results from renography and Cr-51-EDTA plasma clearance were collected from medical records from time of injury until 2012, and the occurrence of renal deterioration was analysed by cumulative incidence curves. The impact of demographics, neurological level and completeness of SCI, urinary tract stones, dilatation of the upper urinary tract (UUT) and bladder-emptying methods were analysed with Cox proportional hazard ratios.Results: The bladder-emptying methods used for the longest period were reflex triggering (63%), bladder expression (22%), indwelling catheter (5%), normal voiding (4%), ileal conduit (3%) and clean intermittent catheterisation (2%). The cumulative risk of moderate renal deterioration (functional distribution outside 40 - 60% on renography or relative glomerular filtration rate (GFR)