Vilsmeier reaction of 3-aminopropenamides: one-pot synthesis of pyrimidin-4(3H)-ones.
Vilsmeier reaction of 3-aminopropenamides: one-pot synthesis of pyrimidin-4(3H)-ones.
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DOI：
10.1021/jo101949y
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发表时间：
2011-03
期刊：
影响因子：
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通讯作者：
Rui Zhang;Dingyuan Zhang;Yongjiu Liang;Guang-Pei Zhou;D. Dong
中科院分区：
文献类型：
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作者：
Rui Zhang;Dingyuan Zhang;Yongjiu Liang;Guang-Pei Zhou;D. Dong
以一系列3-氨基丙烯酰胺为原料，通过与不同的Vilsmeier试剂反应，一锅法合成了嘧啶-4（3 H）-酮，并提出了一个包括卤化、取代和分子内亲核环化的反应机理.
A facile one-pot synthesis of pyrimidin-4(3H)-ones was developed via reactions of a series of readily available 3-aminopropenamides with varied Vilsmeier reagents, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.