A systematic review of compliance to oral nutritional supplements
A systematic review of compliance to oral nutritional supplements
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DOI：
10.1016/j.clnu.2011.11.020
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发表时间：
2012-06-01
影响因子：
6.3
通讯作者：
Stratton, Rebecca J.
中科院分区：
文献类型：
--
作者：
Hubbard, Gary P.;Elia, Marinos;Stratton, Rebecca J.
背景与目的：口服营养补充剂（ONS）在营养不良的管理中起着关键作用。本系统性综述检查了患者对ONS的依从性，以及患者和ONS相关因素的影响。方法：系统性综述确定了46项ONS研究（n 4328），其中可获得依从性数据（占ONS处方量的百分比）。根据研究设计和医疗保健环境，对总体合并平均依从性%进行了评估。依从性和ONS相关和患者相关因素之间的相互关系，以及总能量intake assessed.Results：总体平均依从性与ONS为78%（37%-100%; 67%医院，81%社区;总体平均ONS摄入量433千卡/天）。随机（79%）和非随机（77%）试验的依从性百分比相似，诊断组之间的差异很小。在一组异质的不匹配研究中，依从性与较高能量密度的ONS和较大的ONS以及总能量摄入呈正相关，与年龄呈负相关，与ONS处方量或持续时间无关。这项系统性综述表明，对ONS的依从性良好，尤其是使用高能量密度的ONS，从而改善患者的总能量摄入，这与临床益处有关。需要进一步的研究来解决其他常用口服营养支持方法的依从性和有效性。(C)2011年爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: Oral nutritional supplements (ONS) play a key role in the management of malnutrition. This systematic review examined patients' compliance with ONS across healthcare settings and the influence of patient and ONS-related factors.Methods: A systematic review identified 46 studies (n 4328) of ONS in which data on compliance (% of prescribed quantity of ONS consumed) was available. Pooled mean %compliance was assessed overall and according to study design and healthcare setting. Inter-relationships between compliance and ONS-related and patient-related factors, and total energy intake were assessed.Results: Overall mean compliance with ONS was 78% (37%-100%; 67% hospital, 81% community; overall mean ONS intake 433 kcal/d). Percentage compliance was similar in randomised (79%) and non-randomised (77%) trials, with little variation between diagnostic groups. Compliance across a heterogeneous group of unmatched studies was positively associated with higher energy-density ONS and greater ONS and total energy intakes, negatively associated with age, and unrelated to amount or duration of ONS prescription.Conclusions: This systematic review suggests that compliance to ONS is good, especially with higher energy-density ONS, resulting in improvements in patients' total energy intakes that have been linked with clinical benefits. Further research is required to address the compliance and effectiveness of other common methods of oral nutritional support. (C) 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.