Polymicrobial Biofilm Studies: From Basic Science to Biofilm Control.
Polymicrobial Biofilm Studies: From Basic Science to Biofilm Control.
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DOI：
10.1007/s40496-016-0078-y
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发表时间：
2016-03
影响因子：
--
通讯作者：
Peters BM
中科院分区：
文献类型：
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作者：
Willems HM;Xu Z;Peters BM
微生物很少以单一物种的共生形式存在，因为它们通常在实验室中进行研究。相反，绝大多数作为附着于宿主和环境表面的复杂多微生物生物膜群落的一部分存在。口腔代表了最多样化和研究最充分的多微生物财团之一。尽管在过去的几十年中，机械生物膜研究领域蓬勃发展，但我们对口腔生物膜内微生物成员之间相互作用的理解仍然有限。因此，本次审查的主要目的是集中在多微生物生物膜的形成，微生物的相互作用和介导的口腔生物膜的发展，口腔卫生对局部和全身性疾病的后果，和潜在的治疗策略，以限制口腔微生态失调的信号事件。
Microbes rarely exist as single species planktonic forms as they have been commonly studied in the laboratory. Instead, the vast majority exists as part of complex polymicrobial biofilm communities attached to host and environmental surfaces. The oral cavity represents one of the most diverse and well-studied polymicrobial consortia. Despite a burgeoning field of mechanistic biofilm research within the past decades, our understanding of interactions that occur between microbial members within oral biofilms is still limited. Thus, the primary objective of this review is to focus on polymicrobial biofilm formation, microbial interactions and signaling events that mediate oral biofilm development, consequences of oral hygiene on both local and systemic disease, and potential therapeutic strategies to limit oral dysbiosis.