Evaluation of Ethylcellulose as A Matrix for Prolonged Release Formulations. I. Water Soluble Drugs: Acetaminophen and Theophylline
Evaluation of Ethylcellulose as A Matrix for Prolonged Release Formulations. I. Water Soluble Drugs: Acetaminophen and Theophylline
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DOI：
10.3109/03639048709068380
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发表时间：
1987
影响因子：
3.4
通讯作者：
N. Shaikh;S. Abidi;L. Block
中科院分区：
文献类型：
--
作者：
N. Shaikh;S. Abidi;L. Block
摘要以乙基纤维素为载体，制备相对水溶性药物对乙酰氨基酚和茶碱的缓释固体分散体。采用溶剂法制备了不同粘度等级（21、95、209和350 cps）的乙基纤维素的固体分散体，其浓度分别为药物重量的7.5%、15.0%和30.0%。聚合物的浓度是控制药物释放速度的决定因素，结果表明，随着乙基纤维素用量的增加，药物释放时间延长。乙基纤维素的粘度等级越高，药物从固体分散体中释放的速度越慢。与颗粒状固体分散体相比，片剂的药物释放时间更长。对乙酰氨基酚和茶碱在两种溶出介质中的体外释放量大致相似。乙基纤维素的粘度等级对药物的释放速度影响不大。
AbstractIn this study ethylcellulose was evaluated as a carrier for the preparation of prolonged release solid dispersions of relatively water soluble drugs, acetaminophen and theophylline. The solid dispersions containing various concentrations (7.5, 15.0 and 30.0 % by weight of drug) of ethylcellulose of different viscosity grades (21, 95, 209 and 350 cps) were prepared by the solvent method. The concentration of polymer in the formulation was the determining factor in controlling release rate of the drug, as the results indicate prolongation in release of the drug with increase in amount of ethylcellulose. The higher the viscosity grade of ethylcellulose, slower the release of drug from the solid dispersions. The release of drug from the tablets was more prolonged compared to the granular solid dispersions. In vitro release of acetaminophen and theophylline was more or less similar in both dissolution media. The viscosity grade of ethylcellulose showed slight influence on the release rate of drug from ...