Impact of Vascular Invasion of a Primary Tumor as a Strong Risk Factor for Disease Recurrence in Patients with Node-Positive Breast Cancer
Impact of Vascular Invasion of a Primary Tumor as a Strong Risk Factor for Disease Recurrence in Patients with Node-Positive Breast Cancer
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原发肿瘤血管侵犯是淋巴结阳性乳腺癌患者疾病复发的重要危险因素
DOI：
10.1177/000313481508100537
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
H. Kuwano
中科院分区：
文献类型：
--
作者：
T. Fujii;R. Yajima;Hiroki Morita;T. Hirakata;T. Miyamoto;T. Fujisawa;S. Tsutsumi;Yasuhiro Ynagita;M. Iijima;H. Kuwano
有无淋巴结转移被认为是判断预后最重要的指标。然而，在某些淋巴结阳性乳腺癌病例中，癌细胞传播局限于淋巴系统。因此，为淋巴结阳性乳腺癌患者制定强辅助治疗的选择标准是很重要的。本研究旨在评估淋巴结阳性乳腺癌中血管浸润的存在，它可能反映全身性疾病作为疾病复发的预测因子。我们回顾性分析了134例连续接受乳房根治性手术的女性乳腺癌伴淋巴结转移患者。我们检查了复发与临床病理因素的关系，特别是血管侵犯。在单变量分析中发现血管浸润的存在是显著的。在多变量分析中，存在血管侵犯是独立的危险因素。66例无血管侵犯的患者中，4例（6.1%）有疾病复发。另一方面，68例血管侵犯患者中有15例（22.1%）复发。值得注意的是，尽管存在淋巴结转移，但没有血管侵犯的组很少有远处转移的患者。我们的研究结果表明，血管浸润的存在可能是高生物侵袭性的一个指标，可能是淋巴结阳性乳腺癌的一个强有力的预后因素。
The presence of lymph node metastasis is considered to be the most significant indicator of prognosis. However, in some cases with node-positive breast cancer, cancer cell dissemination is localized to the lymphatic systems. It is, therefore, important to develop selection criteria for strong adjuvant therapy in patients with node-positive breast cancer. This study was undertaken to evaluate the presence of vascular invasion that may reflect systemic disease as a predictor of disease recurrence in node-positive breast cancer. We retrospectively evaluated the cases of 134 consecutive female patients with breast cancer with lymph node metastasis who underwent radical breast operations. We examined the relationship between recurrence and clinicopathological factors, particularly vascular invasion. The presence of vascular invasion was found to be significant in a univariate analysis. The presence of vascular invasion was the independent risk factor in a multivariate analysis. Among the 66 patients without vascular invasion, four (6.1%) had disease recurrence. On the other hand, among the 68 patients with vascular invasion, 15 (22.1%) had a recurrence. It is interesting to note that despite the presence of lymph node metastasis, the group without vascular invasion had few patients with distant metastases. Our results suggest that the presence of vascular invasion could be an indicator of high biological aggressiveness and may be a strong prognostic factor for node-positive breast cancer.
影响因子：
45.3
作者：
Woodward, WA;Strom, EA;Buchholz, TA
通讯作者：
Buchholz, TA