Dopamine modulates excitability of spiny neurons in the avian basal ganglia
Dopamine modulates excitability of spiny neurons in the avian basal ganglia
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DOI：
10.1523/jneurosci.22-12-05210.2002
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发表时间：
2002-06-15
影响因子：
5.3
通讯作者：
Perkel, DJ
中科院分区：
文献类型：
--
作者：
Ding, L;Perkel, DJ
鸣禽发声学习的神经基质是研究脊椎动物运动学习和运动控制的一个可利用的系统。在所谓的歌曲系统中，前前脑通路（AFP），这是必不可少的歌曲学习，类似于哺乳动物基底神经节-丘脑皮质回路在其宏观组织，神经元的内在特性，和微电路。X区是AFP的第一站，其周围的嗅旁叶（LPO）都是鸟类基底神经节的一部分。像哺乳动物一样，它们接受来自中脑的密集多巴胺能神经支配，但这种投射的生理功能仍不清楚。本研究观察了多巴胺（DA）对X区棘状神经元兴奋性和LPO的影响。我们记录了成年斑胸草雀和孟加拉草雀脑切片的神经元，采用全细胞和穿孔膜片钳技术配置。我们发现，DA调节棘神经元的兴奋性;激活D1和D2样DA受体分别增强和降低兴奋性。这些影响是类似的哺乳动物新纹状体中观察到的，与D1样DA受体激活的主要区别是，在超极化状态下的鸟类多刺神经元的兴奋性增强。我们的研究结果还表明，一些多刺神经元表达两种受体类型，并建议受体共定位在整个人口可以占DA行动的频谱。DA动作的多样性使DA系统能够微调歌曲系统的动态，并允许对歌曲学习和制作进行灵活控制。
The neural substrate of vocal learning in songbirds is an accessible system for studying motor learning and motor control in vertebrates. In the so-called song system, the anterior forebrain pathway (AFP), which is essential for song learning, resembles the mammalian basal ganglia-thalamocortical loop in its macroscopic organization, neuronal intrinsic properties, and microcircuitry. Area X, the first station in the AFP, and the surrounding lobus parolfactorius (LPO), are both parts of the avian basal ganglia. Like their mammalian counterparts, they receive dense dopaminergic innervation from the midbrain, but the physiological functions of this projection remain unclear. In this study, we investigated the effect of dopamine (DA) on excitability of spiny neurons in area X and LPO. We recorded from neurons in brain slices of adult zebra finches and Bengalese finches, using whole-cell and perforated-patch recording techniques in current-clamp configuration. We found that DA modulates excitability in spiny neurons; activation of D1- and D2-like DA receptors enhances and reduces excitability, respectively. These effects are similar to those observed in the mammalian neostriatum, with the main difference being that D1- like DA receptor activation enhances excitability in avian spiny neurons at hyperpolarized states. Our findings also indicate that some spiny neurons express both receptor types and suggest that receptor colocalization in the entire population can account for the spectrum of DA actions. The diversity of DA actions enables the DA system to fine-tune the dynamics of the song system and allows flexible control over song learning and production.