Lower cortisol and higher ACTH levels in individuals with autism
Lower cortisol and higher ACTH levels in individuals with autism
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DOI：
10.1023/a:1025019030121
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发表时间：
2003-08-01
影响因子：
3.9
通讯作者：
Susnjara, IM
中科院分区：
文献类型：
--
作者：
Curin, JM;Terzic, J;Susnjara, IM
在36名自闭症患者和27名对照患者中测量了垂体激素、促肾上腺皮质激素（ACTH）、催乳素、生长激素和肾上腺激素皮质醇的血药浓度。与年龄和性别匹配的对照组相比，自闭症患者血清皮质醇浓度显著降低（p < 10(-6)）， ACTH浓度显著升高（p = 0.002）。此外，与正常人相比，患有癫痫的自闭症患者的催乳素浓度明显更高。观察到的激素变化可能表明自闭症患者的下丘脑-垂体-肾上腺轴功能障碍。
Blood concentrations of pituitary hormones adrenocorticotropin (ACTH), prolactin, growth hormone, and adrenal hormone-cortisol were measured in 36 autistic and 27 control individuals. Individuals with autism had significantly lower serum concentrations of cortisol (p < 10(-6)), and significantly higher concentrations of ACTH (p = 0.002) than control age- and sex-matched subjects. Also, prolactin concentrations in autistic patients with epilepsy were significantly higher when compared with normal subjects. The observed hormonal changes may indicate dysfunction of the hypothalamo-pituitary-adrenal axis in individuals with autism.