Uptake and efflux of serotonin from platelets of autistic and nonautistic children
Uptake and efflux of serotonin from platelets of autistic and nonautistic children
复制标题
自闭症和非自闭症儿童血小板中血清素的摄取和流出
DOI：
--
复制
发表时间：
1975
期刊：
影响因子：
--
通讯作者：
Diane Matsuno
中科院分区：
文献类型：
--
作者：
A. Yuwiler;E. Ritvo;E. Geller;Ronald Glousman;Gary Schneiderman;Diane Matsuno
本研究在体外检测了孤独症儿童、非孤独症住院对照病例和正常儿童血小板对5-羟色胺的吸收和流出。自闭症患者是根据先前建立的诊断标准精心挑选的。住院的对照儿童被用来评估可能的环境和饮食对结果的影响。摄取方法与以前的研究者使用的方法相似。两个外排程序被用来探讨的可能性，方法因素占以前报道的自闭症和对照组之间的差异。结果未能表明自闭症患者和住院对照组或正常人之间的吸收或外排有统计学显著差异。方法上的考虑，可能会占未能确认以前的研究结果进行了详细讨论。
This study examined, in vitro, the uptake and efflux of serotonin by platelets from autistic children, nonautistic hospitalized comparison cases, and normal children. The autistic patients were carefully selected according to previously established diagnostic criteria. The hospitalized comparison children were utilized to assess possible environmental and dietary influences upon the results. Uptake methods were similar to those used by previous investigators. Two efflux procedures were utilized to explore the possibility that methodological factors accounted for previously reported differences between autistic and comparison groups. The results failed to indicate statistically significant differences in uptake or efflux between the autistic and the hospitalized comparison groups or the normals. Methodologic considerations which could possibly account for the failure to confirm previous findings are discussed in detail.