Transcriptional control of cell fate in the stomatal lineage.
Transcriptional control of cell fate in the stomatal lineage.
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DOI：
10.1016/j.pbi.2015.09.008
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发表时间：
2016-02
影响因子：
9.5
通讯作者：
Bergmann DC
中科院分区：
文献类型：
--
作者：
Simmons AR;Bergmann DC
拟南芥气孔谱系是发育的一个缩影;它经历了前体细胞的选择、不对称和干细胞样分裂、细胞定型以及最终获得终末细胞命运。最近的转录组学方法揭示了伴随每个命运转变的基因表达的主要变化，并且对关键bHLH转录因子的机制分析，沿着数学建模，已经开始解开这些主要变化是如何协调的。此外，气孔启动被证明是一个易于处理的模型，用于定义稳定的细胞身份的遗传和表观遗传基础，并了解环境响应到发育程序的整合。
The Arabidopsis stomatal lineage is a microcosm of development; it undergoes selection of precursor cells, asymmetric and stem cell-like divisions, cell commitment and finally, acquisition of terminal cell fates. Recent transcriptomic approaches revealed major shifts in gene expression accompanying each fate transition, and mechanistic analysis of key bHLH transcription factors, along with mathematical modeling, has begun to unravel how these major shifts are coordinated. In addition, stomatal initiation is proving to be a tractable model for defining the genetic and epigenetic basis of stable cell identities and for understanding the integration of environmental responses into developmental programs.