Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants
Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants
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DOI：
10.1007/s00213-009-1723-0
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发表时间：
2010-02-01
影响因子：
3.4
通讯作者：
Nathan, Pradeep J.
中科院分区：
文献类型：
--
作者：
Leung, Sumie;Croft, Rodney J.;Nathan, Pradeep J.
精神分裂症通常与前注意变化检测的损伤相关，如由减少的失配负性（MMN）所表示的。虽然MMN的神经化学基础与N-甲基-D-天冬氨酸（NMDA）受体功能有关，但多巴胺能和/或5-羟色胺能系统在人类中的作用尚未完全探讨。16名健康男性受试者参加了一项双盲、安慰剂对照、交叉设计，在4种急性治疗条件下评估每例受试者的MMN持续时间，间隔5天洗脱期：平衡氨基酸控制（无消耗），酪氨酸/苯丙氨酸消耗（减少DA神经传递），色氨酸耗竭（减少5-HT神经传递）和色氨酸/酪氨酸/苯丙氨酸消耗DA和5-HT单独或同时急性耗竭对MMN均无影响，提示DA能和5-HT能系统的急性调节并不导致MMN的改变。
Schizophrenia is commonly associated with impairments in pre-attentive change detection, as represented by reduced mismatch negativity (MMN). While the neurochemical basis of MMN has been linked to N-methyl-d-aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans.The aim of the present study was to investigate the effects of acutely depleting dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) alone or simultaneously by depleting their amino acid precursors on MMN in healthy participants.Sixteen healthy male subjects participated in a double-blind, placebo-controlled, cross-over design in which each subject's duration MMN was assessed under four acute treatment conditions separated by a 5-day washout period: balanced amino acid control (no depletion), tyrosine/phenylalanine depletion (to reduce DA neurotransmission), tryptophan depletion (to reduce 5-HT neurotransmission) and tryptophan/tyrosine/phenylalanine depletion (to reduce DA and 5-HT neurotransmission simultaneously).Acute depletion of either DA and 5-HT alone or simultaneously had no effect on MMN.These findings suggest that modulation of the dopaminergic and serotonergic systems acutely does not lead to changes in MMN.