Cellular pathways influenced by protein arginine methylation: Implications for cancer.
Cellular pathways influenced by protein arginine methylation: Implications for cancer.
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DOI：
10.1016/j.molcel.2021.09.011
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发表时间：
2021-11-04
期刊：
影响因子：
16
通讯作者：
Richard S
中科院分区：
文献类型：
--
作者：
Xu J;Richard S
Arginine methylation is an influential post-translational modification occurring on histones, RNA binding proteins and many other cellular proteins affecting their function by altering their protein-protein and protein-nucleic acid interactions. Recently, a wealth of information has been gathered implicating the protein arginine methyltransferases (PRMTs), the enzymes that deposit arginine methylation, in transcription, pre-mRNA splicing, DNA damage signaling and immune signaling with major implications for cancer therapy, especially immunotherapy. This review will summarize this recent progress and the current state of PRMT inhibitors, some in clinical trials, as promising drug targets for cancer.
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