The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study
The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study
复制标题
DOI：
10.1038/sj.ijo.0803798
复制
发表时间：
2008-05-01
影响因子：
4.9
通讯作者：
Berenson, G. S.
中科院分区：
文献类型：
--
作者：
Freedman, D. S.;Patel, D. A.;Berenson, G. S.
目的：尽管肥胖儿童在以后的生活中患冠心病的风险增加，但尚不清楚这种关联是否与儿童期肥胖持续到成年有关。我们研究了儿童和成人体重指数（BMI, kg m(-2)）水平与平均年龄36岁时测量的颈动脉内膜-中膜厚度（IMT）之间的关系。设计和受试者：在确定成人IMT之前，1142名参与者在Bogalusa心脏研究中接受了7次（平均）检查。测量：除BMI外，每次检查时还测量血脂、脂蛋白和血压水平。每个危险因素的累积水平基于使用重复（BMI）测量的多水平模型计算的个体生长曲线下的面积。然后，我们检查了这些累积水平与成人IMT的关系。结果：颈动脉IMT与儿童期和成年期的BMI累积水平相关(P
Objective: Although obese children are at increased risk for coronary heart disease in later life, it is not clear if the association results from the persistence of childhood obesity into adulthood. We examined the relation of both childhood and adult levels of body mass index (BMI, kg m(-2)) to carotid intima-media thickness (IMT) measured at the (mean) age of 36 years.Design and Subjects: Prior to the determination of adult IMT, the 1142 participants had been examined 7 (mean) times in the Bogalusa Heart Study.Measurements: In addition to BMI, levels of lipids, lipoproteins and blood pressure were measured at each examination. Cumulative levels of each risk factor were based on the areas under the individual growth curves calculated using multilevel models for repeated (BMI) measurements. We then examined the relation of these cumulative levels to adult IMT.Results: Carotid IMT was associated with cumulative levels of BMI in both childhood and adulthood (P