Realization of a 15-channel, hermetically-encased wireless subretinal prosthesis for the blind.
Realization of a 15-channel, hermetically-encased wireless subretinal prosthesis for the blind.
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为盲人实现 15 通道密封无线视网膜下假体。
DOI：
10.1109/iembs.2009.5333619
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Rizzo3rd,JosephF
中科院分区：
文献类型：
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作者：
Kelly,ShawnK;Shire,DouglasB;Chen,Jinghua;Doyle,Patrick;Gingerich,MarcusD;Drohan,WilliamA;Theogarajan,LukeS;Cogan,StuartF;Wyatt,JohnL;Rizzo3rd,JosephF
一种小型化、密封式、无线操作的视网膜假体已被开发出来，用于尤卡坦半岛小型猪动物模型的植入和临床前研究。该假体符合眼睛的形状，并驱动带有溅射氧化铱电极的微加工聚酰亚胺刺激电极阵列。使用专门设计的外部手术技术将该阵列植入视网膜下腔，将假体的大部分固定在巩膜表面。植入设备包括一个密封钛盒，内含 15 通道刺激器芯片和分立电源组件。外壳的馈通连接到次级电源和数据接收线圈。此外，还对电极进行了长期体外脉冲测试，以确保其在密封盒的长使用寿命内的稳定性。最终组件经过体外测试，以验证系统在生物盐水中使用定制射频发射器电路和初级线圈的无线操作。使用定制图形用户界面对刺激脉冲强度、持续时间和频率进行无线编程。通过使用隐形眼镜电极测量眼睛表面的刺激伪影，已经在一头猪体内验证了视网膜植入物的操作超过三个月。
A miniaturized, hermetically-encased, wirelessly-operated retinal prosthesis has been developed for implantation and pre-clinical studies in Yucatan mini-pig animal models. The prosthesis conforms to the eye and drives a microfabricated polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially-designed ab externo surgical technique that affixes the bulk of the prosthesis to the surface of the sclera. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete power supply components. Feedthroughs from the case connect to secondary power- and data-receiving coils. In addition, long-term in vitro pulse testing was performed on the electrodes to ensure their stability for the long lifetime of the hermetic case. The final assembly was tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a custom graphical user interface. Operation of the retinal implant has been verified in vivo in one pig for more than three months by measuring stimulus artifacts on the eye surface using a contact lens electrode.