Cell Fate Decision Making through Oriented Cell Division.
Cell Fate Decision Making through Oriented Cell Division.
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DOI：
10.3390/jdb3040129
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发表时间：
2015-12
影响因子：
2.7
通讯作者：
Johnston CA
中科院分区：
文献类型：
--
作者：
Dewey EB;Taylor DT;Johnston CA
决定细胞命运的能力在动物发育过程中至关重要。此外，忠实地执行这一过程可以确保整个成年期的组织稳态，而所涉及的分子机制的缺陷可能会导致疾病。进化上保守的蛋白质复合物控制不同组织的细胞命运决定。因此，在有丝分裂过程中维持这些决定因素的正确子细胞遗传模式是细胞命运决策过程的基本步骤。在这篇综述中，我们将讨论两个关键方面的命运决定因素分离活动，皮质细胞极性和有丝分裂纺锤体的方向，以及它们如何共同作用，产生定向细胞分裂，最终影响子细胞的命运。我们的重点将是针对主要的潜在分子机制和特定的细胞命运的决定，他们已经被证明控制。
The ability to dictate cell fate decisions is critical during animal development. Moreover, faithful execution of this process ensures proper tissue homeostasis throughout adulthood, whereas defects in the molecular machinery involved may contribute to disease. Evolutionarily conserved protein complexes control cell fate decisions across diverse tissues. Maintaining proper daughter cell inheritance patterns of these determinants during mitosis is therefore a fundamental step of the cell fate decision-making process. In this review, we will discuss two key aspects of this fate determinant segregation activity, cortical cell polarity and mitotic spindle orientation, and how they operate together to produce oriented cell divisions that ultimately influence daughter cell fate. Our focus will be directed at the principal underlying molecular mechanisms and the specific cell fate decisions they have been shown to control.