Toxic Epidermal Necrolysis in a Child Successfully Treated with Infliximab
Toxic Epidermal Necrolysis in a Child Successfully Treated with Infliximab
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DOI：
10.1111/pde.12029
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发表时间：
2014-07-01
影响因子：
1.5
通讯作者：
Mckay, David
中科院分区：
文献类型：
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作者：
Scott-Lang, Victoria;Tidman, Michael;Mckay, David
一个7岁的男孩发展严重中毒性表皮坏死松解症（TEN）继发于卡马西平，并被转移到我们的中心后，进一步恶化，尽管接受了一剂静脉注射免疫球蛋白。给予一剂英夫利西单抗后，水泡的进展明显停止，并有明显的显着改善。我们认为英夫利西单抗的给药可能导致该儿童的改善，并且考虑到可能的潜在病理过程，抗肿瘤坏死因子-α治疗可能是TEN的合理治疗。迫切需要对任何此类治疗的安全性和有效性进行良好的研究。
A 7-year-old boy developed severe toxic epidermal necrolysis (TEN) secondary to carbamazepine and was transferred to our center after further deterioration despite receiving one dose of intravenous immunoglobulin. After administration of one dose of infliximab, there was a clear halting of progression of blistering and an apparent dramatic improvement. We consider it likely that the administration of infliximab led to the improvement in this child and that anti-tumor necrosis factor-alpha therapy may be a logical treatment for TEN, given the possible underlying pathologic process. Well-conducted studies on the safety and efficacy of any such treatment are urgently required.