Prospective associations between somatic illness and mental illness from childhood to adulthood.
Prospective associations between somatic illness and mental illness from childhood to adulthood.
复制标题
从童年到成年躯体疾病和精神疾病之间的前瞻性关联。
DOI：
10.1093/oxfordjournals.aje.a009442
复制
发表时间：
1998
影响因子：
5
通讯作者：
Brook,J
中科院分区：
文献类型：
--
作者：
Cohen,P;Pine,DS;Must,A;Kasen,S;Brook,J
躯体疾病和精神疾病之间的联系在成人中已经很好地建立起来，但在儿童和青少年中则不太清楚。在纽约北部随机选择了700多名儿童，从1975年的1-10岁到1992年的青年人进行了研究。精神和身体健康进行了评估，通过后续的青年和家长访谈，在8年，2年半和6年的时间间隔（1983年，1985-1986年，1991-1993年）。横断面和纵向分析调查：1）儿童期身体疾病和精神疾病之间关系的一致性; 2）重性抑郁症（MDD）在解释这种关系方面的特异性; 3）免疫介导的医学疾病在这种关系中的特异性;以及4）这种关系是否归因于与低社会经济地位相关的风险。在横断面上，所有年龄段的健康状况不佳与精神疾病风险增加相关，显著比值比（OR）范围为1.76至3.26。在前瞻性分析中，健康状况不佳增加了所有年龄段新发MDD的风险（OR = 2.05-4.48）。MDD也预测随后的健康状况不佳，独立于先前的健康问题（OR = 3.81和4.04）。关系不归因于家庭社会经济地位。MDD和与免疫因素改变相关的医学疾病之间的关联特别强（OR = 1.83-6.41）。常见的免疫介导的医学疾病和抑郁症的脆弱性的理论与这些协会是一致的。美国流行病学杂志1998; 147：232-9。
The association between somatic illness and psychiatric illness is well established in adults but is less clear in childhood and adolescence. A cohort of over 700 randomly selected children in Upstate New York were studied from ages 1–10 years in 1975 to young adulthood in 1992. Psychiatric and physical health were assessed by means of follow-up youth and parent interviews at 8-, 2½- and 6-year intervals (in 1983, 1985–1986, and 1991–1993). Cross-sectional and longitudinal analyses investigated: 1) the consistency of the relation between physical illness and mental illness in childhood; 2) the specificity of major depressive disorder (MDD) in accounting for the relation; 3) the specificity of immunologically mediated medical disorders in this relation; and 4) whether this relation was attributable to risks associated with low socioeconomic status. Cross-sectionally, ill health was associated with increased risk of psychiatric disorders at all ages, with significant odds ratios (ORs) ranging from 1.76 to 3.26. In prospective analyses, ill health increased the risk of new-onset MDD at all ages (ORs = 2.05–4.48). MDD also predicted subsequent ill health, independent of prior health problems (ORs = 3.81 and 4.04). Relations were not attributable to familial socioeconomic status. Associations were particularly strong between MDD and medical disorders associated with alterations in immunologic factors (ORs = 1.83–6.41). Theories of common immune-mediated vulnerabilities to medical illness and depression are consistent with these associations.Am J Epidemiol1998; 147: 232–9.