Emergence of Japanese encephalitis among adults 40 years of age or older in northern China: Epidemiological and clinical characteristics
Emergence of Japanese encephalitis among adults 40 years of age or older in northern China: Epidemiological and clinical characteristics
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DOI：
10.1111/tbed.13945
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发表时间：
2020-12-20
影响因子：
4.3
通讯作者：
Wang, Huanyu
中科院分区：
文献类型：
--
作者：
Wu, Dan;Chen, Xiaojing;Wang, Huanyu
日本脑炎（乙脑）是一种媒介传播的疫苗可预防的传染病，疫苗可提供直接保护。2007年，中国在全国范围内对幼儿进行了乙脑疫苗接种，迅速实现了高覆盖率。2018年，中国报告乙脑病例1,800例，发病率和死亡率分别为0.13/10万和0.0097/10万。在全国范围内，64%的病例发生在40岁或40岁以上的成年人中，在中国北方，82%的病例发生在成年人中，主要发生在暴发期间。不同年龄组的严重程度差别不大。与前10年相比，成人病例的比例和绝对数均有所上升，表明在儿童乙脑减少的同时，中国可能出现成人乙脑。我们描述了日本脑炎流行病学和临床特征，全国和低流行率的地区后，超过10年的常规儿童乙脑疫苗接种。应优先确定人群乙脑血清阳性率;应考虑在高危地区开展成人疫苗接种运动。
Japanese encephalitis (JE) is a vector-borne vaccine preventable infectious disease for which vaccine provides direct protection. China introduced nationwide JE vaccination of young children in 2007, rapidly achieving high coverage. In 2018, 1,800 JE cases were reported in China, with morbidity and mortality rates of 0.13/100,000 and 0.0097/100,000. Nationally, 64% of cases were among adults aged 40 years or older, and in northern China, 82% were among adults, mainly in outbreaks. Severity varied little by age grouping. Compared with the previous 10 years, the proportion and absolute number of cases among adults increased, indicating possible emergence of adult JE in China as childhood JE decreased. We describe JE epidemiology and clinical features nationally and in areas with low endemicity after more than 10 years of routine childhood JE vaccination. Determining population JE seroprevalence should be a priority; vaccination campaigns among adults in high risk areas should be considered.