Viral warts (Human Papilloma Virus) as a potential risk for breast cancer among younger females
Viral warts (Human Papilloma Virus) as a potential risk for breast cancer among younger females
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DOI：
10.1016/j.cmpb.2017.03.024
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发表时间：
2017-06-01
影响因子：
6.1
通讯作者：
Syed-Abdul, Shabbir
中科院分区：
文献类型：
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作者：
Atique, Suleman;Hsieh, Chung-Ho;Syed-Abdul, Shabbir
前言：关于人乳头瘤病毒（HPV）在乳腺癌病因学中的作用已有几篇报道。据我们所知，这是第一个研究使用疾病-疾病关联数据挖掘方法来分析病毒性疣和乳腺癌进行在Taiwan population.Materials和方法：我们分析了台湾的国民健康保险数据库（NHIDM数据包括23万例患者数据），以检查病毒性疣和女性乳腺癌之间的关联。患者被分为三组：仅乳腺癌，仅病毒疣，以及乳腺癌和病毒疣。考克斯比例风险回归分析用于衡量HPV对乳腺癌诊断时间的影响。多变量分析和分层分析，使用风险比（HR）与95%的置信区间（CI）调整后的年龄，和CCI. Results：在807,578 HPV人群中，我们确定了6014例乳腺癌病例。HPV感染组患乳腺癌的风险显著增高（HR，1.18; 95%CI，1.15-1.21; p
Introduction: There have been several reports on the role of human papillomavirus (HPV) in the etiology of breast cancer. To our knowledge, this is first study to use disease-disease association data-mining approach to analyzing viral warts and breast cancer to be conducted in Taiwanese population.Materials and methods: We analyzed the Taiwan's National Health Insurance database (NHIDM data comprising of 23 million patient data) to examine the association between viral warts and female breast carcinoma. The patients were categorized into three groups: breast cancer only, viral warts only, and those with both breast cancer and viral warts. The Cox proportion hazard regression analysis was used to measure the effect of HPV on the time to breast cancer diagnosis. Multivariable analyzes and stratified analyzes using hazard ratios (HRs) were presented with 95% confidence intervals (CIs) after adjusting for age, and CCI.Result: Among 807,578 HPV population, we identified 6014 breast cancer cases. The HPV group was associated with a significantly higher risk of developing breast cancer (HR, 1.18; 95% CI, 1.15-1.21; p